http://computchem.org/cs/wikis/computchem/default.aspxen-USCommunityServer 2008.5 SP1 (Build: 31106.3070)http://computchem.org/cs/wikis/computchem/replica-exchange-with-mmtsb-in-parallel/revision/0.aspxMon, 19 Jul 2010 15:29:33 GMT1b863b40-6314-48da-8368-fb96d4c4a8e3:9JasonCurrent revision posted to Computational Chemistry and Biophysics Wiki by Jason on 7/19/2010 10:29:33 AM<br /> <p>you can run replica exchange using MMTSB script aarex.pl using parallel processes for each replica.</p> <p>You need to compile charmm using open-mpi or another parallel package that allows aarex.pl to communicate </p> <p>with charmm interactively. (MPICH didn&#39;t not work for us).</p> <p>1 ) first compile charmm with Open-MPI ( i used options )</p> <p>./install gnu large M gfortran X86_64</p> <p>3 ) you need to make a hostlist file, upon jobs submission, that has the number of replicas you will use on each node. </p> <p>I am running one replica on each node, and each replica is using 4 cpus. You can make this file using the following awk commans in your submission script</p> <p>&gt;&gt; echo $LSB_HOSTS | tr -cs &#39;a-z0-90-9&#39; &#39;[\n*]&#39;| awk &#39;{count[$1]++} END {for(name in count) print name,count[name]/4,&quot; /scratch/jason&quot;}&#39; &gt; hostlist</p> <p>and the file looks like this..</p> <p>node1 [scratch directory] 1</p> <p>node2 [scratch directory] 1</p> <p>....</p> <p>2 ) then use openmpi options for aarex.pl ( here are example aarex.pl arguments I used )</p> <p>aarex.pl -charmmexec $MPICHARMM \<br />-mp -hosts hostlist \<br />-openmpi 4 /opt/openmpi_pcc/1.2.4/bin/mpirun \<br />-n 4005 -charmmlog logfile -log rexlog \</p> <p>see http://feig.bch.msu.edu/mmtsb/aarex.pl for additional details</p>http://computchem.org/cs/wikis/computchem/definitions-of-oligopeptides-and-polypeptides/revision/0.aspxSat, 08 May 2010 15:46:22 GMT1b863b40-6314-48da-8368-fb96d4c4a8e3:8StevenWangCurrent revision posted to Computational Chemistry and Biophysics Wiki by StevenWang on 5/8/2010 10:46:22 AM<br /> <h2><span style="text-decoration: line-through; color: red;">Definition</span> <span style="background: SpringGreen;">Definitions</span> of Oligopeptides and Polypeptides</h2> <div style="font-size: 90%;">Filed under: <span style="text-decoration: line-through; color: red;">Definitions</span></div> <p>The definition usually used in biochemistry: &quot;peptides with fewer than about 10-20 resides&quot; are also called oligopeptides. For those with more than 10-20 residues, they are called polypeptides. [1]</p> <p>&nbsp;</p> <p>References:</p> <p>1. International Union of Biochemistry. Nomenclatures and symbolism for Amino Acids and Peptides<i>.&nbsp; Pure Appl. Chem. </i><b>1984</b><i>, 56:</i>595-624<i> </i><a href="http://www.iupac.org/publications/pac/1984/pdf/5605x0595.pdf">(LINK)</a><i><br /></i></p>http://computchem.org/cs/wikis/computchem/definitions-of-oligopeptides-and-polypeptides/revision/1.aspxSat, 08 May 2010 15:46:02 GMT1b863b40-6314-48da-8368-fb96d4c4a8e3:66StevenWangRevision 1 posted to Computational Chemistry and Biophysics Wiki by StevenWang on 5/8/2010 10:46:02 AM<br /> <p>The definition usually used in biochemistry: &quot;peptides with fewer than about 10-20 resides&quot; are also called oligopeptides. For those with more than 10-20 residues, they are called polypeptides. [1]</p> <p>&nbsp;</p> <p>References:</p> <p>1. International Union of Biochemistry. Nomenclatures and symbolism for Amino Acids and Peptides<i>.&nbsp; Pure Appl. Chem. </i><b>1984</b><i>, 56:</i>595-624<i> </i><a href="http://www.iupac.org/publications/pac/1984/pdf/5605x0595.pdf">(LINK)</a><i><br /></i></p>http://computchem.org/cs/wikis/computchem/definition-of-proteins/revision/0.aspxSat, 08 May 2010 15:40:36 GMT1b863b40-6314-48da-8368-fb96d4c4a8e3:6StevenWangCurrent revision posted to Computational Chemistry and Biophysics Wiki by StevenWang on 5/8/2010 10:40:36 AM<br /> <h2>Definition of Proteins</h2> <div style="font-size: 90%;">Filed under: <span style="text-decoration: line-through; color: red;">Definitions</span></div> <p>The general definition: Proteins are &quot;naturally occurring and synthetic <i>polypeptides</i> having molecular weights greater than about 10,000 (the limit is not precise).&quot; [1]</p> <p>The definition usually used in biochemistry: proteins are <i>polypeptides</i> with specific sequence that contains more than 50 residues [2]. </p> <p>&nbsp;</p> <p>&nbsp;</p> <p>References:</p> <p>1. G. P. Moss, P. A. S. Smith and D. Tavernier.<i> </i>Glossary of class names of organic compounds and reactivity intermediates based on structure.<i> Pure. Appl. Chem. </i><b>1995</b><i>, 67:</i>1307-1375<i> </i><b><a href="http://iupac.org/publications/pac/67/8/1307/">(LINK)</a></b><i></i></p> <p><i>2. </i>International Union of Biochemistry. Nomenclatures and symbolism for Amino Acids and Peptides<i>.&nbsp; Pure Appl. <span style="text-decoration: line-through; color: red;">chem</span><span style="background: SpringGreen;">Chem</span>. </i><b>1984</b><i>, 56:</i>595-624<i> </i><a href="http://www.iupac.org/publications/pac/1984/pdf/5605x0595.pdf">(LINK)</a><i><br /></i></p>http://computchem.org/cs/wikis/computchem/definition-of-proteins/revision/1.aspxSat, 08 May 2010 15:24:37 GMT1b863b40-6314-48da-8368-fb96d4c4a8e3:65StevenWangRevision 1 posted to Computational Chemistry and Biophysics Wiki by StevenWang on 5/8/2010 10:24:37 AM<br /> <p>The general definition: Proteins are &quot;naturally occurring and synthetic <i>polypeptides</i> having molecular weights greater than about 10,000 (the limit is not precise).&quot; [1]</p> <p>The definition usually used in biochemistry: proteins are <i>polypeptides</i> with specific sequence that contains more than 50 residues [2]. </p> <p>&nbsp;</p> <p>&nbsp;</p> <p>References:</p> <p>1. G. P. Moss, P. A. S. Smith and D. Tavernier.<i> </i>Glossary of class names of organic compounds and reactivity intermediates based on structure.<i> Pure. Appl. Chem. </i><b>1995</b><i>, 67:</i>1307-1375<i> </i><b><a href="http://iupac.org/publications/pac/67/8/1307/">(LINK)</a></b><i></i></p> <p><i>2. </i>International Union of Biochemistry. Nomenclatures and symbolism for Amino Acids and Peptides<i>.&nbsp; Pure Appl. chem. </i><b>1984</b><i>, 56:</i>595-624<i> </i><a href="http://www.iupac.org/publications/pac/1984/pdf/5605x0595.pdf">(LINK)</a><b></b><i><br /></i></p>http://computchem.org/cs/wikis/computchem/definition-of-peptides/revision/0.aspxSat, 08 May 2010 15:40:16 GMT1b863b40-6314-48da-8368-fb96d4c4a8e3:7StevenWangCurrent revision posted to Computational Chemistry and Biophysics Wiki by StevenWang on 5/8/2010 10:40:16 AM<br /> <h2>Definition of Peptides</h2> <div style="font-size: 90%;">Filed under: <span style="text-decoration: line-through; color: red;">Definitions</span></div> <p>The general definition: peptides are &quot;amides derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another with formal loss of water.&quot; And &quot;the term is usually applied to structures formed from alpha-amino acids, but it includes those derived from any amino carboxylic acid&quot;. [1]</p> <p>The definition usually used in biochemistry: &quot;a peptide is any compound produced by amide formation between a carboxyl group of one amino acid and an amino group of another. The amide bonds in peptides may be called peptide bonds. The word peptide usually applies to compounds whose amide bonds are formed between C-1 of one amino acids and N-2 of another (sometimes called eupeptide bonds), but it includes compounds with residues linked by another amide bonds (sometimes called isopeptide bonds).&quot; [2]</p> <p>&nbsp;</p> <p>References:</p> <p>1. G. P. Moss, P. A. S. Smith and D. Tavernier.<i> </i>Glossary of class names of organic compounds and reactivity intermediates based on structure.<i> Pure. Appl. Chem. </i><b>1995</b><i>, 67:</i>1307-1375<i> </i><b><a href="http://iupac.org/publications/pac/67/8/1307/">(LINK)</a></b></p> <p><i>2. </i>International Union of Biochemistry. Nomenclatures and symbolism for Amino Acids and Peptides<i>.&nbsp; Pure Appl. <span style="text-decoration: line-through; color: red;">chem</span><span style="background: SpringGreen;">Chem</span>. </i><b>1984</b><i>, 56:</i>595-624<i> </i><a href="http://www.iupac.org/publications/pac/1984/pdf/5605x0595.pdf">(LINK)</a><i><br /></i></p>http://computchem.org/cs/wikis/computchem/definition-of-peptides/revision/1.aspxSat, 08 May 2010 15:39:23 GMT1b863b40-6314-48da-8368-fb96d4c4a8e3:64StevenWangRevision 1 posted to Computational Chemistry and Biophysics Wiki by StevenWang on 5/8/2010 10:39:23 AM<br /> <p>The general definition: peptides are &quot;amides derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another with formal loss of water.&quot; And &quot;the term is usually applied to structures formed from alpha-amino acids, but it includes those derived from any amino carboxylic acid&quot;. [1]</p> <p>The definition usually used in biochemistry: &quot;a peptide is any compound produced by amide formation between a carboxyl group of one amino acid and an amino group of another. The amide bonds in peptides may be called peptide bonds. The word peptide usually applies to compounds whose amide bonds are formed between C-1 of one amino acids and N-2 of another (sometimes called eupeptide bonds), but it includes compounds with residues linked by another amide bonds (sometimes called isopeptide bonds).&quot; [2]</p> <p>&nbsp;</p> <p>References:</p> <p>1. G. P. Moss, P. A. S. Smith and D. Tavernier.<i> </i>Glossary of class names of organic compounds and reactivity intermediates based on structure.<i> Pure. Appl. Chem. </i><b>1995</b><i>, 67:</i>1307-1375<i> </i><b><a href="http://iupac.org/publications/pac/67/8/1307/">(LINK)</a></b></p> <p><i>2. </i>International Union of Biochemistry. Nomenclatures and symbolism for Amino Acids and Peptides<i>.&nbsp; Pure Appl. chem. </i><b>1984</b><i>, 56:</i>595-624<i> </i><a href="http://www.iupac.org/publications/pac/1984/pdf/5605x0595.pdf">(LINK)</a><i><br /></i></p>http://computchem.org/cs/wikis/computchem/image-charge-effect/revision/0.aspxTue, 09 Mar 2010 18:16:19 GMT1b863b40-6314-48da-8368-fb96d4c4a8e3:5StevenWangCurrent revision posted to Computational Chemistry and Biophysics Wiki by StevenWang on 3/9/2010 12:16:19 PM<br /> <h2>Image charge effect</h2> <div style="font-size: 90%;">Filed under: <span style="text-decoration: line-through; color: red;">Electrostatics</span></div> <p>The term &quot;image charge effect&quot; comes from the image charge method, which is a general way to simplify the calculation of the interaction between a charge and a dielectric interface or a conductor, on the basis of the &quot;uniqueness theorem&quot; [1].</p> <p>I. image charge effects due to the dielectric interface<br />&nbsp;&nbsp; The resulting effects of the presence of a dielectric interface are the following:<br />Imagine a water-oil interface,<br />&nbsp;&nbsp; 1. If a charge is put in the high dielectric phase (water), then the charge experiences a repulsive force from the dielectric boundary.<br />&nbsp;&nbsp; 2. If a charge is put in the low dielectric phase (oil), then the charge experiences an attractive force from the interface.<br /><br />II. image charge effects due to a conductor surface<br />&nbsp;&nbsp;&nbsp;&nbsp; Because of the restraint that the electric field lines have to be always perpendicular to the conductor surface, the image charge is always of the opposite sign of the original charge.<br /><br />III. Applications<br />&nbsp;&nbsp; The image charge effect can be conveniently used to explain many phenomenas. One of them is the pKa shift of an ionizable probe near the water-oil boundary of the micelles [2].<br /><br />&nbsp;<br /><br />References:<br /><br />1. Ken A. Dill and Sarina Bromberg. <i>Molecular Driving Forces</i>. Garland Science, New York and London, 2003, p399-406.<br />2. Soderman <i>et al</i>. J. Phys. Chem. B. 2006, 110, 3288.</p>http://computchem.org/cs/wikis/computchem/image-charge-effect/revision/5.aspxTue, 09 Mar 2010 18:15:41 GMT1b863b40-6314-48da-8368-fb96d4c4a8e3:63StevenWangRevision 5 posted to Computational Chemistry and Biophysics Wiki by StevenWang on 3/9/2010 12:15:41 PM<br /> <h2>Image charge effect</h2> <div style="font-size: 90%;">Filed under: Electrostatics</div> <p>The term &quot;image charge effect&quot; comes from the image charge method, which is a general way to simplify the calculation of the interaction between a charge and a dielectric interface or a conductor, on the basis of the &quot;uniqueness theorem&quot; [1].</p> <p>I. image charge effects due to the dielectric interface<br />&nbsp;&nbsp; The resulting effects of the presence of a dielectric interface are the following:<br />Imagine a water-oil interface,<br />&nbsp;&nbsp; 1. If a charge is put in the high dielectric phase (water), then the charge experiences a repulsive force from the dielectric boundary.<br />&nbsp;&nbsp; 2. If a charge is put in the low dielectric phase (oil), then the charge experiences an attractive force from the interface.<br /><br />II. image charge effects due to a conductor surface<br />&nbsp;&nbsp;&nbsp;&nbsp; Because of the restraint that the electric field lines have to be always perpendicular to the conductor surface, the image charge is always of the opposite sign of the original charge.<br /><br />III. Applications<br />&nbsp;&nbsp; The image charge effect can be conveniently used to explain many phenomenas. One of them is the pKa shift of an ionizable probe near the water-oil boundary of the micelles [2].<br /><br />&nbsp;<br /><br />References:<br /><br />1. Ken A. Dill and Sarina Bromberg. <i>Molecular Driving Forces</i>. Garland Science, New York and London, 2003, p399-406.<br />2. Soderman et al. J. Phys. Chem. B. 2006, 110, 3288.</p>http://computchem.org/cs/wikis/computchem/image-charge-effect/revision/4.aspxTue, 09 Mar 2010 18:12:39 GMT1b863b40-6314-48da-8368-fb96d4c4a8e3:62StevenWangRevision 4 posted to Computational Chemistry and Biophysics Wiki by StevenWang on 3/9/2010 12:12:39 PM<br /> <h2>Image charge effect</h2> <div style="font-size: 90%;">Filed under: Electrostatics</div> <p>The term &quot;image charge effect&quot; comes from the image charge method, which is a general way to simplify the calculation of the interaction between a charge and a dielectric interface or a conductor, on the basis of the &quot;uniqueness theorem&quot; [1].</p> <p>I. image charge effects due to the dielectric interface<br />&nbsp;&nbsp; The resulting effects of the presence of a dielectric interface are the following:<br />Imagine a water-oil interface,<br />&nbsp;&nbsp; 1. If a charge is put in the high dielectric phase (water), then the charge experiences a repulsive force from the dielectric boundary.<br />&nbsp;&nbsp; 2. If a charge is put in the low dielectric phase (oil), then the charge experiences an attractive force from the interface.<br /><br />II. image charge effects due to a conductor surface<br />&nbsp;&nbsp;&nbsp;&nbsp; Because of the restraint that the electric field lines have to be always perpendicular to the conductor surface, the image charge is always of the opposite sign of the original charge.<br /><br />III. Applications<br />&nbsp;&nbsp; The image charge effect can be conveniently used to explain many phenomenas. One of them is the pKa shift of an ionizable probe near the water-oil boundary of the micelles [2].<br /><br />&nbsp;<br /><br />References:<br /><br />1. Ken A. Dill and Sarina Bromberg. Molecular Driving Forces. Garland Science, New York and London, 2003, p399-406.<br />2. Soderman et al. J. Phys. Chem. B. 2006, 110, 3288.</p>http://computchem.org/cs/wikis/computchem/image-charge-effect/revision/3.aspxTue, 09 Mar 2010 18:11:47 GMT1b863b40-6314-48da-8368-fb96d4c4a8e3:61StevenWangRevision 3 posted to Computational Chemistry and Biophysics Wiki by StevenWang on 3/9/2010 12:11:47 PM<br /> <h2>Image charge effect</h2> <div style="font-size: 90%;">Filed under: Electrostatics</div> <p><span style="background: SpringGreen;">The</span> <span style="background: SpringGreen;">term</span> <span style="background: SpringGreen;">&quot;image</span> <span style="background: SpringGreen;">charge</span> <span style="background: SpringGreen;">effect</span><span style="background: SpringGreen;">&quot;</span> <span style="background: SpringGreen;">comes</span> <span style="background: SpringGreen;">from</span> <span style="background: SpringGreen;">the</span> <span style="background: SpringGreen;">image</span> <span style="background: SpringGreen;">charge</span> <span style="background: SpringGreen;">method</span><span style="background: SpringGreen;">,</span> <span style="background: SpringGreen;">which</span> <span style="background: SpringGreen;">is</span> <span style="background: SpringGreen;">a</span> <span style="background: SpringGreen;">general</span> <span style="background: SpringGreen;">way</span> <span style="background: SpringGreen;">to</span> <span style="background: SpringGreen;">simplify</span> <span style="background: SpringGreen;">the</span> <span style="background: SpringGreen;">calculation</span> <span style="background: SpringGreen;">of</span> <span style="background: SpringGreen;">the</span> <span style="background: SpringGreen;">interaction</span> <span style="background: SpringGreen;">between</span> <span style="background: SpringGreen;">a</span> <span style="background: SpringGreen;">charge</span> <span style="background: SpringGreen;">and</span> <span style="background: SpringGreen;">a</span> <span style="background: SpringGreen;">dielectric</span> <span style="background: SpringGreen;">interface</span> <span style="background: SpringGreen;">or</span> <span style="background: SpringGreen;">a</span> <span style="background: SpringGreen;">conductor</span><span style="background: SpringGreen;">,</span> <span style="background: SpringGreen;">on</span> <span style="background: SpringGreen;">the</span> <span style="background: SpringGreen;">basis</span> <span style="background: SpringGreen;">of</span> <span style="background: SpringGreen;">the</span> <span style="background: SpringGreen;">&quot;uniqueness</span> <span style="background: SpringGreen;">theorem</span><span style="background: SpringGreen;">&quot;</span> <span style="background: SpringGreen;">[</span><span style="background: SpringGreen;">1].</span></p> <p><span style="background: SpringGreen;">I</span><span style="background: SpringGreen;">.</span> <span style="background: SpringGreen;">image</span> <span style="background: SpringGreen;">charge</span> <span style="background: SpringGreen;">effects</span> <span style="background: SpringGreen;">due</span> <span style="background: SpringGreen;">to</span> <span style="background: SpringGreen;">the</span> <span style="background: SpringGreen;">dielectric</span> <span style="background: SpringGreen;">interface</span><br />&nbsp;&nbsp; <span style="background: SpringGreen;">The</span> <span style="background: SpringGreen;">resulting</span> <span style="background: SpringGreen;">effects</span> <span style="background: SpringGreen;">of</span> <span style="background: SpringGreen;">the</span> <span style="background: SpringGreen;">presence</span> <span style="background: SpringGreen;">of</span> <span style="background: SpringGreen;">a</span> <span style="background: SpringGreen;">dielectric</span> <span style="background: SpringGreen;">interface</span> <span style="background: SpringGreen;">are</span> <span style="background: SpringGreen;">the</span> <span style="background: SpringGreen;">following</span><span style="background: SpringGreen;">:</span><br /><span style="background: SpringGreen;">Imagine</span> <span style="background: SpringGreen;">a</span> <span style="background: SpringGreen;">water-oil</span> <span style="background: SpringGreen;">interface</span><span style="background: SpringGreen;">,</span><br />&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <span style="background: SpringGreen;">1</span><span style="background: SpringGreen;">.</span> <span style="background: SpringGreen;">If</span> <span style="background: SpringGreen;">a</span> <span style="background: SpringGreen;">charge</span> <span style="background: SpringGreen;">is</span> <span style="background: SpringGreen;">put</span> <span style="background: SpringGreen;">in</span> <span style="background: SpringGreen;">the</span> <span style="background: SpringGreen;">high</span> <span style="background: SpringGreen;">dielectric</span> <span style="background: SpringGreen;">phase</span> <span style="background: SpringGreen;">(</span><span style="background: SpringGreen;">water),</span> <span style="background: SpringGreen;">then</span> <span style="background: SpringGreen;">the</span> <span style="background: SpringGreen;">charge</span> <span style="background: SpringGreen;">experiences</span> <span style="background: SpringGreen;">a</span> <span style="background: SpringGreen;">repulsive</span> <span style="background: SpringGreen;">force</span> <span style="background: SpringGreen;">from</span> <span style="background: SpringGreen;">the</span> <span style="background: SpringGreen;">dielectric</span> <span style="background: SpringGreen;">boundary</span><span style="background: SpringGreen;">.</span><br />&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <span style="background: SpringGreen;">2</span><span style="background: SpringGreen;">.</span> <span style="background: SpringGreen;">If</span> <span style="background: SpringGreen;">a</span> <span style="background: SpringGreen;">charge</span> <span style="background: SpringGreen;">is</span> <span style="background: SpringGreen;">put</span> <span style="background: SpringGreen;">in</span> <span style="background: SpringGreen;">the</span> <span style="background: SpringGreen;">low</span> <span style="background: SpringGreen;">dielectric</span> <span style="background: SpringGreen;">phase</span> <span style="background: SpringGreen;">(</span><span style="background: SpringGreen;">oil),</span> <span style="background: SpringGreen;">then</span> <span style="background: SpringGreen;">the</span> <span style="background: SpringGreen;">charge</span> <span style="background: SpringGreen;">experiences</span> <span style="background: SpringGreen;">an</span> <span style="background: SpringGreen;">attractive</span> <span style="background: SpringGreen;">force</span> <span style="background: SpringGreen;">from</span> <span style="background: SpringGreen;">the</span> <span style="background: SpringGreen;">interface</span><span style="background: SpringGreen;">.</span><br /><br /><span style="background: SpringGreen;">II</span><span style="background: SpringGreen;">.</span> <span style="background: SpringGreen;">image</span> <span style="background: SpringGreen;">charge</span> <span style="background: SpringGreen;">effects</span> <span style="background: SpringGreen;">due</span> <span style="background: SpringGreen;">to</span> <span style="background: SpringGreen;">a</span> <span style="background: SpringGreen;">conductor</span> <span style="background: SpringGreen;">surface</span><br />&nbsp;&nbsp;&nbsp;&nbsp; <span style="background: SpringGreen;">Because</span> <span style="background: SpringGreen;">of</span> <span style="background: SpringGreen;">the</span> <span style="background: SpringGreen;">restraint</span> <span style="background: SpringGreen;">that</span> <span style="background: SpringGreen;">the</span> <span style="background: SpringGreen;">electric</span> <span style="background: SpringGreen;">field</span> <span style="background: SpringGreen;">lines</span> <span style="background: SpringGreen;">have</span> <span style="background: SpringGreen;">to</span> <span style="background: SpringGreen;">be</span> <span style="background: SpringGreen;">always</span> <span style="background: SpringGreen;">perpendicular</span> <span style="background: SpringGreen;">to</span> <span style="background: SpringGreen;">the</span> <span style="background: SpringGreen;">conductor</span> <span style="background: SpringGreen;">surface</span><span style="background: SpringGreen;">,</span> <span style="background: SpringGreen;">the</span> <span style="background: SpringGreen;">image</span> <span style="background: SpringGreen;">charge</span> <span style="background: SpringGreen;">is</span> <span style="background: SpringGreen;">always</span> <span style="background: SpringGreen;">of</span> <span style="background: SpringGreen;">the</span> <span style="background: SpringGreen;">opposite</span> <span style="background: SpringGreen;">sign</span> <span style="background: SpringGreen;">of</span> <span style="background: SpringGreen;">the</span> <span style="background: SpringGreen;">original</span> <span style="background: SpringGreen;">charge</span><span style="background: SpringGreen;">.</span><br /><br /><span style="background: SpringGreen;">III</span><span style="background: SpringGreen;">.</span> <span style="background: SpringGreen;">Applications</span><br />&nbsp;&nbsp; <span style="background: SpringGreen;">The</span> <span style="background: SpringGreen;">image</span> <span style="background: SpringGreen;">charge</span> <span style="background: SpringGreen;">effect</span> <span style="background: SpringGreen;">can</span> <span style="background: SpringGreen;">be</span> <span style="background: SpringGreen;">conveniently</span> <span style="background: SpringGreen;">used</span> <span style="background: SpringGreen;">to</span> <span style="background: SpringGreen;">explain</span> <span style="background: SpringGreen;">many</span> <span style="background: SpringGreen;">phenomenas</span><span style="background: SpringGreen;">.</span> <span style="background: SpringGreen;">One</span> <span style="background: SpringGreen;">of</span> <span style="background: SpringGreen;">them</span> <span style="background: SpringGreen;">is</span> <span style="background: SpringGreen;">the</span> <span style="background: SpringGreen;">pKa</span> <span style="background: SpringGreen;">shift</span> <span style="background: SpringGreen;">of</span> <span style="background: SpringGreen;">an</span> <span style="background: SpringGreen;">ionizable</span> <span style="background: SpringGreen;">probe</span> <span style="background: SpringGreen;">near</span> <span style="background: SpringGreen;">the</span> <span style="background: SpringGreen;">water-oil</span> <span style="background: SpringGreen;">boundary</span> <span style="background: SpringGreen;">of</span> <span style="background: SpringGreen;">the</span> <span style="background: SpringGreen;">micelles</span> <span style="background: SpringGreen;">[</span><span style="background: SpringGreen;">2].</span><br /><br />&nbsp;<br /><br /><span style="background: SpringGreen;">References</span><span style="background: SpringGreen;">:</span><br /><br />1<span style="background: SpringGreen;">.</span> <span style="background: SpringGreen;">Ken</span> <span style="background: SpringGreen;">A</span><span style="background: SpringGreen;">.</span> <span style="background: SpringGreen;">Dill</span> <span style="background: SpringGreen;">and</span> <span style="background: SpringGreen;">Sarina</span> <span style="background: SpringGreen;">Bromberg</span><span style="background: SpringGreen;">.</span> <span style="background: SpringGreen;">Molecular</span> <span style="background: SpringGreen;">Driving</span> <span style="background: SpringGreen;">Forces</span><span style="background: SpringGreen;">.</span> <span style="background: SpringGreen;">Garland</span> <span style="background: SpringGreen;">Science</span><span style="background: SpringGreen;">,</span> <span style="background: SpringGreen;">New</span> <span style="background: SpringGreen;">York</span> <span style="background: SpringGreen;">and</span> <span style="background: SpringGreen;">London</span><span style="background: SpringGreen;">,</span> <span style="background: SpringGreen;">2003</span><span style="background: SpringGreen;">,</span> <span style="background: SpringGreen;">p399-406</span><span style="background: SpringGreen;">.</span><br /><span style="background: SpringGreen;">2</span><span style="background: SpringGreen;">.</span> <span style="background: SpringGreen;">Soderman</span> <span style="background: SpringGreen;">et</span> <span style="background: SpringGreen;">al</span><span style="background: SpringGreen;">.</span> <span style="background: SpringGreen;">J</span><span style="background: SpringGreen;">.</span> <span style="background: SpringGreen;">Phys</span><span style="background: SpringGreen;">.</span> <span style="background: SpringGreen;">Chem</span><span style="background: SpringGreen;">.</span> <span style="background: SpringGreen;">B</span><span style="background: SpringGreen;">.</span> <span style="background: SpringGreen;">2006</span><span style="background: SpringGreen;">,</span> <span style="background: SpringGreen;">110</span><span style="background: SpringGreen;">,</span> <span style="background: SpringGreen;">3288</span><span style="background: SpringGreen;">.</span></p>http://computchem.org/cs/wikis/computchem/image-charge-effect/revision/2.aspxTue, 09 Mar 2010 18:07:30 GMT1b863b40-6314-48da-8368-fb96d4c4a8e3:60StevenWangRevision 2 posted to Computational Chemistry and Biophysics Wiki by StevenWang on 3/9/2010 12:07:30 PM<br /> <h2>Image charge effect</h2> <div style="font-size: 90%;">Filed under: Electrostatics</div> <p> <span style="text-decoration: line-through; color: red;">&lt;meta</span> <span style="text-decoration: line-through; color: red;">http-equiv=</span><span style="text-decoration: line-through; color: red;">&quot;Content-Type&quot;</span> <span style="text-decoration: line-through; color: red;">content=</span><span style="text-decoration: line-through; color: red;">&quot;text/html;</span> <span style="text-decoration: line-through; color: red;">charset=utf-8</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;meta</span> <span style="text-decoration: line-through; color: red;">name=</span><span style="text-decoration: line-through; color: red;">&quot;ProgId&quot;</span> <span style="text-decoration: line-through; color: red;">content=</span><span style="text-decoration: line-through; color: red;">&quot;Word.Document&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;meta</span> <span style="text-decoration: line-through; color: red;">name=</span><span style="text-decoration: line-through; color: red;">&quot;Generator&quot;</span> <span style="text-decoration: line-through; color: red;">content=</span><span style="text-decoration: line-through; color: red;">&quot;Microsoft</span> <span style="text-decoration: line-through; color: red;">Word</span> <span style="text-decoration: line-through; color: red;">12</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;meta</span> <span style="text-decoration: line-through; color: red;">name=</span><span style="text-decoration: line-through; color: red;">&quot;Originator&quot;</span> <span style="text-decoration: line-through; color: red;">content=</span><span style="text-decoration: line-through; color: red;">&quot;Microsoft</span> <span style="text-decoration: line-through; color: red;">Word</span> <span style="text-decoration: line-through; color: red;">12</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;link</span> <span style="text-decoration: line-through; color: red;">rel=</span><span style="text-decoration: line-through; color: red;">&quot;File-List&quot;</span> <span style="text-decoration: line-through; color: red;">href=</span><span style="text-decoration: line-through; color: red;">&quot;file:///C:\Users\Steven\AppData\Local\Temp\msohtmlclip1\01\clip_filelist.xml&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;link</span> <span style="text-decoration: line-through; color: red;">rel=</span><span style="text-decoration: line-through; color: red;">&quot;Preview&quot;</span> <span style="text-decoration: line-through; color: red;">href=</span><span style="text-decoration: line-through; color: red;">&quot;file:///C:\Users\Steven\AppData\Local\Temp\msohtmlclip1\01\clip_preview.wmf&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;!--[if</span> <span style="text-decoration: line-through; color: red;">gte</span> <span style="text-decoration: line-through; color: red;">mso</span> <span style="text-decoration: line-through; color: red;">9</span><span style="text-decoration: line-through; color: red;">]</span><span style="text-decoration: line-through; color: red;">&gt;&lt;xml&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;o:DocumentProperties&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;o:Version&gt;12.00&lt;/o:Version&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;/o:DocumentProperties&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;/xml&gt;&lt;![endif]--&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;link</span> <span style="text-decoration: line-through; color: red;">rel=</span><span style="text-decoration: line-through; color: red;">&quot;themeData&quot;</span> <span style="text-decoration: line-through; color: red;">href=</span><span style="text-decoration: line-through; color: red;">&quot;file:///C:\Users\Steven\AppData\Local\Temp\msohtmlclip1\01\clip_themedata.thmx&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;link</span> <span style="text-decoration: line-through; color: red;">rel=</span><span style="text-decoration: line-through; color: red;">&quot;colorSchemeMapping&quot;</span> <span style="text-decoration: line-through; color: red;">href=</span><span style="text-decoration: line-through; color: red;">&quot;file:///C:\Users\Steven\AppData\Local\Temp\msohtmlclip1\01\clip_colorschememapping.xml&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;!--[if</span> <span style="text-decoration: line-through; color: red;">gte</span> <span style="text-decoration: line-through; color: red;">mso</span> <span style="text-decoration: line-through; color: red;">9</span><span style="text-decoration: line-through; color: red;">]</span><span style="text-decoration: line-through; color: red;">&gt;&lt;xml&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:WordDocument&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:View&gt;Normal&lt;/w:View&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:Zoom&gt;0&lt;/w:Zoom&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:TrackMoves</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:TrackFormatting</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:PunctuationKerning</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:ValidateAgainstSchemas</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:SaveIfXMLInvalid&gt;false&lt;/w:SaveIfXMLInvalid&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:IgnoreMixedContent&gt;false&lt;/w:IgnoreMixedContent&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:AlwaysShowPlaceholderText&gt;false&lt;/w:AlwaysShowPlaceholderText&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:DoNotPromoteQF</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LidThemeOther&gt;EN-US&lt;/w:LidThemeOther&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LidThemeAsian&gt;ZH-CN&lt;/w:LidThemeAsian&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LidThemeComplexScript&gt;X-NONE&lt;/w:LidThemeComplexScript&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:Compatibility&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:BreakWrappedTables</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:SnapToGridInCell</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:WrapTextWithPunct</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:UseAsianBreakRules</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:DontGrowAutofit</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:SplitPgBreakAndParaMark</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:DontVertAlignCellWithSp</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:DontBreakConstrainedForcedTables</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:DontVertAlignInTxbx</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:Word11KerningPairs</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:CachedColBalance</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;/w:Compatibility&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:BrowserLevel&gt;MicrosoftInternetExplorer4&lt;/w:BrowserLevel&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;m:mathPr&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;m:mathFont</span> <span style="text-decoration: line-through; color: red;">m:val=</span><span style="text-decoration: line-through; color: red;">&quot;Cambria</span> <span style="text-decoration: line-through; color: red;">Math</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;m:brkBin</span> <span style="text-decoration: line-through; color: red;">m:val=</span><span style="text-decoration: line-through; color: red;">&quot;before&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;m:brkBinSub</span> <span style="text-decoration: line-through; color: red;">m:val=</span><span style="text-decoration: line-through; color: red;">&quot;&amp;#45;-&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;m:smallFrac</span> <span style="text-decoration: line-through; color: red;">m:val=</span><span style="text-decoration: line-through; color: red;">&quot;off&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;m:dispDef</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;m:lMargin</span> <span style="text-decoration: line-through; color: red;">m:val=</span><span style="text-decoration: line-through; color: red;">&quot;0&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;m:rMargin</span> <span style="text-decoration: line-through; color: red;">m:val=</span><span style="text-decoration: line-through; color: red;">&quot;0&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;m:defJc</span> <span style="text-decoration: line-through; color: red;">m:val=</span><span style="text-decoration: line-through; color: red;">&quot;centerGroup&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;m:wrapIndent</span> <span style="text-decoration: line-through; color: red;">m:val=</span><span style="text-decoration: line-through; color: red;">&quot;1440&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;m:intLim</span> <span style="text-decoration: line-through; color: red;">m:val=</span><span style="text-decoration: line-through; color: red;">&quot;subSup&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;m:naryLim</span> <span style="text-decoration: line-through; color: red;">m:val=</span><span style="text-decoration: line-through; color: red;">&quot;undOvr&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;/m:mathPr&gt;&lt;/w:WordDocument&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;/xml&gt;&lt;![endif]--&gt;&lt;!--[if</span> <span style="text-decoration: line-through; color: red;">gte</span> <span style="text-decoration: line-through; color: red;">mso</span> <span style="text-decoration: line-through; color: red;">9</span><span style="text-decoration: line-through; color: red;">]</span><span style="text-decoration: line-through; color: red;">&gt;&lt;xml&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LatentStyles</span> <span style="text-decoration: line-through; color: red;">DefLockedState=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">DefUnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;true&quot;</span> <span style="text-decoration: line-through; color: red;">DefSemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;true&quot;</span> <span style="text-decoration: line-through; color: red;">DefQFormat=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">DefPriority=</span><span style="text-decoration: line-through; color: red;">&quot;99&quot;</span> <span style="text-decoration: line-through; color: red;">LatentStyleCount=</span><span style="text-decoration: line-through; color: red;">&quot;267&quot;&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;0&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">QFormat=</span><span style="text-decoration: line-through; color: red;">&quot;true&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Normal&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;9&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">QFormat=</span><span style="text-decoration: line-through; color: red;">&quot;true&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;heading</span> <span style="text-decoration: line-through; color: red;">1</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;9&quot;</span> <span style="text-decoration: line-through; color: red;">QFormat=</span><span style="text-decoration: line-through; color: red;">&quot;true&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;heading</span> <span style="text-decoration: line-through; color: red;">2</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;9&quot;</span> <span style="text-decoration: line-through; color: red;">QFormat=</span><span style="text-decoration: line-through; color: red;">&quot;true&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;heading</span> <span style="text-decoration: line-through; color: red;">3</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;9&quot;</span> <span style="text-decoration: line-through; color: red;">QFormat=</span><span style="text-decoration: line-through; color: red;">&quot;true&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;heading</span> <span style="text-decoration: line-through; color: red;">4</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;9&quot;</span> <span style="text-decoration: line-through; color: red;">QFormat=</span><span style="text-decoration: line-through; color: red;">&quot;true&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;heading</span> <span style="text-decoration: line-through; color: red;">5</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;9&quot;</span> <span style="text-decoration: line-through; color: red;">QFormat=</span><span style="text-decoration: line-through; color: red;">&quot;true&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;heading</span> <span style="text-decoration: line-through; color: red;">6</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;9&quot;</span> <span style="text-decoration: line-through; color: red;">QFormat=</span><span style="text-decoration: line-through; color: red;">&quot;true&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;heading</span> <span style="text-decoration: line-through; color: red;">7</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;9&quot;</span> <span style="text-decoration: line-through; color: red;">QFormat=</span><span style="text-decoration: line-through; color: red;">&quot;true&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;heading</span> <span style="text-decoration: line-through; color: red;">8</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;9&quot;</span> <span style="text-decoration: line-through; color: red;">QFormat=</span><span style="text-decoration: line-through; color: red;">&quot;true&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;heading</span> <span style="text-decoration: line-through; color: red;">9</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;39&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;toc</span> <span style="text-decoration: line-through; color: red;">1</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;39&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;toc</span> <span style="text-decoration: line-through; color: red;">2</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;39&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;toc</span> <span style="text-decoration: line-through; color: red;">3</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;39&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;toc</span> <span style="text-decoration: line-through; color: red;">4</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;39&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;toc</span> <span style="text-decoration: line-through; color: red;">5</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;39&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;toc</span> <span style="text-decoration: line-through; color: red;">6</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;39&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;toc</span> <span style="text-decoration: line-through; color: red;">7</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;39&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;toc</span> <span style="text-decoration: line-through; color: red;">8</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;39&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;toc</span> <span style="text-decoration: line-through; color: red;">9</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;35&quot;</span> <span style="text-decoration: line-through; color: red;">QFormat=</span><span style="text-decoration: line-through; color: red;">&quot;true&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;caption&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;10&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">QFormat=</span><span style="text-decoration: line-through; color: red;">&quot;true&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Title&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;1&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Default</span> <span style="text-decoration: line-through; color: red;">Paragraph</span> <span style="text-decoration: line-through; color: red;">Font</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;11&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">QFormat=</span><span style="text-decoration: line-through; color: red;">&quot;true&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Subtitle&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;22&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">QFormat=</span><span style="text-decoration: line-through; color: red;">&quot;true&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Strong&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;20&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">QFormat=</span><span style="text-decoration: line-through; color: red;">&quot;true&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Emphasis&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;59&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Table</span> <span style="text-decoration: line-through; color: red;">Grid</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Placeholder</span> <span style="text-decoration: line-through; color: red;">Text</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;1&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">QFormat=</span><span style="text-decoration: line-through; color: red;">&quot;true&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;No</span> <span style="text-decoration: line-through; color: red;">Spacing</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;60&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Light</span> <span style="text-decoration: line-through; color: red;">Shading</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;61&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Light</span> <span style="text-decoration: line-through; color: red;">List</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;62&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Light</span> <span style="text-decoration: line-through; color: red;">Grid</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;63&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Medium</span> <span style="text-decoration: line-through; color: red;">Shading</span> <span style="text-decoration: line-through; color: red;">1</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;64&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Medium</span> <span style="text-decoration: line-through; color: red;">Shading</span> <span style="text-decoration: line-through; color: red;">2</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;65&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Medium</span> <span style="text-decoration: line-through; color: red;">List</span> <span style="text-decoration: line-through; color: red;">1</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;66&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Medium</span> <span style="text-decoration: line-through; color: red;">List</span> <span style="text-decoration: line-through; color: red;">2</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;67&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Medium</span> <span style="text-decoration: line-through; color: red;">Grid</span> <span style="text-decoration: line-through; color: red;">1</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;68&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Medium</span> <span style="text-decoration: line-through; color: red;">Grid</span> <span style="text-decoration: line-through; color: red;">2</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;69&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Medium</span> <span style="text-decoration: line-through; color: red;">Grid</span> <span style="text-decoration: line-through; color: red;">3</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;70&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Dark</span> <span style="text-decoration: line-through; color: red;">List</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;71&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Colorful</span> <span style="text-decoration: line-through; color: red;">Shading</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;72&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Colorful</span> <span style="text-decoration: line-through; color: red;">List</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;73&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Colorful</span> <span style="text-decoration: line-through; color: red;">Grid</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;60&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Light</span> <span style="text-decoration: line-through; color: red;">Shading</span> <span style="text-decoration: line-through; color: red;">Accent</span> <p>1<span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;61&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Light</span> <span style="text-decoration: line-through; color: red;">List</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">1</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;62&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Light</span> <span style="text-decoration: line-through; color: red;">Grid</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">1</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;63&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Medium</span> <span style="text-decoration: line-through; color: red;">Shading</span> <span style="text-decoration: line-through; color: red;">1</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">1</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;64&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Medium</span> <span style="text-decoration: line-through; color: red;">Shading</span> <span style="text-decoration: line-through; color: red;">2</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">1</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;65&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Medium</span> <span style="text-decoration: line-through; color: red;">List</span> <span style="text-decoration: line-through; color: red;">1</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">1</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Revision&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;34&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">QFormat=</span><span style="text-decoration: line-through; color: red;">&quot;true&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;List</span> <span style="text-decoration: line-through; color: red;">Paragraph</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;29&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">QFormat=</span><span style="text-decoration: line-through; color: red;">&quot;true&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Quote&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;30&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">QFormat=</span><span style="text-decoration: line-through; color: red;">&quot;true&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Intense</span> <span style="text-decoration: line-through; color: red;">Quote</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;66&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Medium</span> <span style="text-decoration: line-through; color: red;">List</span> <span style="text-decoration: line-through; color: red;">2</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">1</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;67&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Medium</span> <span style="text-decoration: line-through; color: red;">Grid</span> <span style="text-decoration: line-through; color: red;">1</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">1</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;68&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Medium</span> <span style="text-decoration: line-through; color: red;">Grid</span> <span style="text-decoration: line-through; color: red;">2</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">1</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;69&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Medium</span> <span style="text-decoration: line-through; color: red;">Grid</span> <span style="text-decoration: line-through; color: red;">3</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">1</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;70&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Dark</span> <span style="text-decoration: line-through; color: red;">List</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">1</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;71&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Colorful</span> <span style="text-decoration: line-through; color: red;">Shading</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">1</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;72&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Colorful</span> <span style="text-decoration: line-through; color: red;">List</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">1</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;73&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Colorful</span> <span style="text-decoration: line-through; color: red;">Grid</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">1</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;60&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Light</span> <span style="text-decoration: line-through; color: red;">Shading</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">2</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;61&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Light</span> <span style="text-decoration: line-through; color: red;">List</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">2</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;62&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Light</span> <span style="text-decoration: line-through; color: red;">Grid</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">2</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;63&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Medium</span> <span style="text-decoration: line-through; color: red;">Shading</span> <span style="text-decoration: line-through; color: red;">1</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">2</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;64&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Medium</span> <span style="text-decoration: line-through; color: red;">Shading</span> <span style="text-decoration: line-through; color: red;">2</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">2</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;65&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Medium</span> <span style="text-decoration: line-through; color: red;">List</span> <span style="text-decoration: line-through; color: red;">1</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">2</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;66&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Medium</span> <span style="text-decoration: line-through; color: red;">List</span> <span style="text-decoration: line-through; color: red;">2</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">2</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;67&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Medium</span> <span style="text-decoration: line-through; color: red;">Grid</span> <span style="text-decoration: line-through; color: red;">1</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">2</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;68&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Medium</span> <span style="text-decoration: line-through; color: red;">Grid</span> <span style="text-decoration: line-through; color: red;">2</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">2</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;69&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Medium</span> <span style="text-decoration: line-through; color: red;">Grid</span> <span style="text-decoration: line-through; color: red;">3</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">2</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;70&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Dark</span> <span style="text-decoration: line-through; color: red;">List</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">2</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;71&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Colorful</span> <span style="text-decoration: line-through; color: red;">Shading</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">2</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;72&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Colorful</span> <span style="text-decoration: line-through; color: red;">List</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">2</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;73&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Colorful</span> <span style="text-decoration: line-through; color: red;">Grid</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">2</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;60&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Light</span> <span style="text-decoration: line-through; color: red;">Shading</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">3</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;61&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Light</span> <span style="text-decoration: line-through; color: red;">List</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">3</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;62&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Light</span> <span style="text-decoration: line-through; color: red;">Grid</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">3</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;63&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Medium</span> <span style="text-decoration: line-through; color: red;">Shading</span> <span style="text-decoration: line-through; color: red;">1</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">3</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;64&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Medium</span> <span style="text-decoration: line-through; color: red;">Shading</span> <span style="text-decoration: line-through; color: red;">2</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">3</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;65&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Medium</span> <span style="text-decoration: line-through; color: red;">List</span> <span style="text-decoration: line-through; color: red;">1</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">3</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;66&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Medium</span> <span style="text-decoration: line-through; color: red;">List</span> <span style="text-decoration: line-through; color: red;">2</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">3</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;67&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Medium</span> <span style="text-decoration: line-through; color: red;">Grid</span> <span style="text-decoration: line-through; color: red;">1</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">3</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;68&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Medium</span> <span style="text-decoration: line-through; color: red;">Grid</span> <span style="text-decoration: line-through; color: red;">2</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">3</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;69&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Medium</span> <span style="text-decoration: line-through; color: red;">Grid</span> <span style="text-decoration: line-through; color: red;">3</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">3</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;70&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Dark</span> <span style="text-decoration: line-through; color: red;">List</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">3</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;71&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Colorful</span> <span style="text-decoration: line-through; color: red;">Shading</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">3</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;72&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Colorful</span> <span style="text-decoration: line-through; color: red;">List</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">3</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;73&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Colorful</span> <span style="text-decoration: line-through; color: red;">Grid</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">3</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;60&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Light</span> <span style="text-decoration: line-through; color: red;">Shading</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">4</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;61&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Light</span> <span style="text-decoration: line-through; color: red;">List</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">4</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;62&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Light</span> <span style="text-decoration: line-through; color: red;">Grid</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">4</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;63&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Medium</span> <span style="text-decoration: line-through; color: red;">Shading</span> <span style="text-decoration: line-through; color: red;">1</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">4</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;64&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Medium</span> <span style="text-decoration: line-through; color: red;">Shading</span> <span style="text-decoration: line-through; color: red;">2</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">4</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;65&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Medium</span> <span style="text-decoration: line-through; color: red;">List</span> <span style="text-decoration: line-through; color: red;">1</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">4</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;66&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Medium</span> <span style="text-decoration: line-through; color: red;">List</span> <span style="text-decoration: line-through; color: red;">2</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">4</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;67&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Medium</span> <span style="text-decoration: line-through; color: red;">Grid</span> <span style="text-decoration: line-through; color: red;">1</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">4</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;68&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Medium</span> <span style="text-decoration: line-through; color: red;">Grid</span> <span style="text-decoration: line-through; color: red;">2</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">4</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;69&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Medium</span> <span style="text-decoration: line-through; color: red;">Grid</span> <span style="text-decoration: line-through; color: red;">3</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">4</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;70&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Dark</span> <span style="text-decoration: line-through; color: red;">List</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">4</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;71&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Colorful</span> <span style="text-decoration: line-through; color: red;">Shading</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">4</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;72&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Colorful</span> <span style="text-decoration: line-through; color: red;">List</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">4</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;73&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Colorful</span> <span style="text-decoration: line-through; color: red;">Grid</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">4</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;60&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Light</span> <span style="text-decoration: line-through; color: red;">Shading</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">5</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;61&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Light</span> <span style="text-decoration: line-through; color: red;">List</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">5</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;62&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Light</span> <span style="text-decoration: line-through; color: red;">Grid</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">5</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;63&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Medium</span> <span style="text-decoration: line-through; color: red;">Shading</span> <span style="text-decoration: line-through; color: red;">1</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">5</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;64&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Medium</span> <span style="text-decoration: line-through; color: red;">Shading</span> <span style="text-decoration: line-through; color: red;">2</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">5</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;65&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Medium</span> <span style="text-decoration: line-through; color: red;">List</span> <span style="text-decoration: line-through; color: red;">1</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">5</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;66&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Medium</span> <span style="text-decoration: line-through; color: red;">List</span> <span style="text-decoration: line-through; color: red;">2</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">5</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;67&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Medium</span> <span style="text-decoration: line-through; color: red;">Grid</span> <span style="text-decoration: line-through; color: red;">1</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">5</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;68&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Medium</span> <span style="text-decoration: line-through; color: red;">Grid</span> <span style="text-decoration: line-through; color: red;">2</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">5</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;69&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Medium</span> <span style="text-decoration: line-through; color: red;">Grid</span> <span style="text-decoration: line-through; color: red;">3</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">5</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;70&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Dark</span> <span style="text-decoration: line-through; color: red;">List</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">5</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;71&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Colorful</span> <span style="text-decoration: line-through; color: red;">Shading</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">5</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;72&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Colorful</span> <span style="text-decoration: line-through; color: red;">List</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">5</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;73&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Colorful</span> <span style="text-decoration: line-through; color: red;">Grid</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">5</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;60&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Light</span> <span style="text-decoration: line-through; color: red;">Shading</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">6</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;61&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Light</span> <span style="text-decoration: line-through; color: red;">List</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">6</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;62&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Light</span> <span style="text-decoration: line-through; color: red;">Grid</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">6</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;63&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Medium</span> <span style="text-decoration: line-through; color: red;">Shading</span> <span style="text-decoration: line-through; color: red;">1</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">6</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;64&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Medium</span> <span style="text-decoration: line-through; color: red;">Shading</span> <span style="text-decoration: line-through; color: red;">2</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">6</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;65&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Medium</span> <span style="text-decoration: line-through; color: red;">List</span> <span style="text-decoration: line-through; color: red;">1</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">6</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;66&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Medium</span> <span style="text-decoration: line-through; color: red;">List</span> <span style="text-decoration: line-through; color: red;">2</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">6</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;67&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Medium</span> <span style="text-decoration: line-through; color: red;">Grid</span> <span style="text-decoration: line-through; color: red;">1</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">6</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;68&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Medium</span> <span style="text-decoration: line-through; color: red;">Grid</span> <span style="text-decoration: line-through; color: red;">2</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">6</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;69&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Medium</span> <span style="text-decoration: line-through; color: red;">Grid</span> <span style="text-decoration: line-through; color: red;">3</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">6</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;70&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Dark</span> <span style="text-decoration: line-through; color: red;">List</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">6</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;71&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Colorful</span> <span style="text-decoration: line-through; color: red;">Shading</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">6</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;72&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Colorful</span> <span style="text-decoration: line-through; color: red;">List</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">6</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;73&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Colorful</span> <span style="text-decoration: line-through; color: red;">Grid</span> <span style="text-decoration: line-through; color: red;">Accent</span> <span style="text-decoration: line-through; color: red;">6</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;19&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">QFormat=</span><span style="text-decoration: line-through; color: red;">&quot;true&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Subtle</span> <span style="text-decoration: line-through; color: red;">Emphasis</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;21&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">QFormat=</span><span style="text-decoration: line-through; color: red;">&quot;true&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Intense</span> <span style="text-decoration: line-through; color: red;">Emphasis</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;31&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">QFormat=</span><span style="text-decoration: line-through; color: red;">&quot;true&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Subtle</span> <span style="text-decoration: line-through; color: red;">Reference</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;32&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">QFormat=</span><span style="text-decoration: line-through; color: red;">&quot;true&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Intense</span> <span style="text-decoration: line-through; color: red;">Reference</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;33&quot;</span> <span style="text-decoration: line-through; color: red;">SemiHidden=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">UnhideWhenUsed=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">QFormat=</span><span style="text-decoration: line-through; color: red;">&quot;true&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Book</span> <span style="text-decoration: line-through; color: red;">Title</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;37&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;Bibliography&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;w:LsdException</span> <span style="text-decoration: line-through; color: red;">Locked=</span><span style="text-decoration: line-through; color: red;">&quot;false&quot;</span> <span style="text-decoration: line-through; color: red;">Priority=</span><span style="text-decoration: line-through; color: red;">&quot;39&quot;</span> <span style="text-decoration: line-through; color: red;">QFormat=</span><span style="text-decoration: line-through; color: red;">&quot;true&quot;</span> <span style="text-decoration: line-through; color: red;">Name=</span><span style="text-decoration: line-through; color: red;">&quot;TOC</span> <span style="text-decoration: line-through; color: red;">Heading</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;/w:LatentStyles&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;/xml&gt;&lt;![endif]--&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;style&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;!--</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">*</span> <span style="text-decoration: line-through; color: red;">Font</span> <span style="text-decoration: line-through; color: red;">Definitions</span> <span style="text-decoration: line-through; color: red;">*</span><span style="text-decoration: line-through; color: red;">/</span> <span style="text-decoration: line-through; color: red;">@</span><span style="text-decoration: line-through; color: red;">font-face</span> <span style="text-decoration: line-through; color: red;">{</span><span style="text-decoration: line-through; color: red;">font-family:</span><span style="text-decoration: line-through; color: red;">&quot;Cambria</span> <span style="text-decoration: line-through; color: red;">Math</span><span style="text-decoration: line-through; color: red;">&quot;;</span> <span style="text-decoration: line-through; color: red;">panose-1:2</span> <span style="text-decoration: line-through; color: red;">4</span> <span style="text-decoration: line-through; color: red;">5</span> <span style="text-decoration: line-through; color: red;">3</span> <span style="text-decoration: line-through; color: red;">5</span> <span style="text-decoration: line-through; color: red;">4</span> <span style="text-decoration: line-through; color: red;">6</span> <span style="text-decoration: line-through; color: red;">3</span> <span style="text-decoration: line-through; color: red;">2</span> <span style="text-decoration: line-through; color: red;">4</span><span style="text-decoration: line-through; color: red;">;</span> <span style="text-decoration: line-through; color: red;">mso-font-charset:0</span><span style="text-decoration: line-through; color: red;">;</span> <span style="text-decoration: line-through; color: red;">mso-generic-font-family:roman</span><span style="text-decoration: line-through; color: red;">;</span> <span style="text-decoration: line-through; color: red;">mso-font-pitch:variable</span><span style="text-decoration: line-through; color: red;">;</span> <span style="text-decoration: line-through; color: red;">mso-font-signature:-1610611985</span> <span style="text-decoration: line-through; color: red;">1107304683</span> <span style="text-decoration: line-through; color: red;">0</span> <span style="text-decoration: line-through; color: red;">0</span> <span style="text-decoration: line-through; color: red;">159</span> <span style="text-decoration: line-through; color: red;">0;</span><span style="text-decoration: line-through; color: red;">}</span> <span style="text-decoration: line-through; color: red;">@</span><span style="text-decoration: line-through; color: red;">font-face</span> <span style="text-decoration: line-through; color: red;">{</span><span style="text-decoration: line-through; color: red;">font-family:</span><span style="text-decoration: line-through; color: red;">&quot;Andale</span> <span style="text-decoration: line-through; color: red;">Sans</span> <span style="text-decoration: line-through; color: red;">UI</span><span style="text-decoration: line-through; color: red;">&quot;;</span> <span style="text-decoration: line-through; color: red;">mso-font-alt</span><span style="text-decoration: line-through; color: red;">:</span><span style="text-decoration: line-through; color: red;">&quot;Arial</span> <span style="text-decoration: line-through; color: red;">Unicode</span> <span style="text-decoration: line-through; color: red;">MS</span><span style="text-decoration: line-through; color: red;">&quot;;</span> <span style="text-decoration: line-through; color: red;">mso-font-charset:0</span><span style="text-decoration: line-through; color: red;">;</span> <span style="text-decoration: line-through; color: red;">mso-generic-font-family:auto</span><span style="text-decoration: line-through; color: red;">;</span> <span style="text-decoration: line-through; color: red;">mso-font-pitch:variable</span><span style="text-decoration: line-through; color: red;">;</span> <span style="text-decoration: line-through; color: red;">mso-font-signature:0</span> <span style="text-decoration: line-through; color: red;">0</span> <span style="text-decoration: line-through; color: red;">0</span> <span style="text-decoration: line-through; color: red;">0</span> <span style="text-decoration: line-through; color: red;">0</span> <span style="text-decoration: line-through; color: red;">0;</span><span style="text-decoration: line-through; color: red;">}</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">*</span> <span style="text-decoration: line-through; color: red;">Style</span> <span style="text-decoration: line-through; color: red;">Definitions</span> <span style="text-decoration: line-through; color: red;">*</span><span style="text-decoration: line-through; color: red;">/</span> <span style="text-decoration: line-through; color: red;">p.MsoNormal</span><span style="text-decoration: line-through; color: red;">,</span> <span style="text-decoration: line-through; color: red;">li.MsoNormal</span><span style="text-decoration: line-through; color: red;">,</span> <span style="text-decoration: line-through; color: red;">div.MsoNormal</span> <span style="text-decoration: line-through; color: red;">{</span><span style="text-decoration: line-through; color: red;">mso-style-unhide:no;</span> <span style="text-decoration: line-through; color: red;">mso-style-qformat:yes</span><span style="text-decoration: line-through; color: red;">;</span> <span style="text-decoration: line-through; color: red;">mso-style-parent</span><span style="text-decoration: line-through; color: red;">:</span><span style="text-decoration: line-through; color: red;">&quot;&quot;;</span> <span style="text-decoration: line-through; color: red;">margin:0in</span><span style="text-decoration: line-through; color: red;">;</span> <span style="text-decoration: line-through; color: red;">margin-bottom:.0001pt</span><span style="text-decoration: line-through; color: red;">;</span> <span style="text-decoration: line-through; color: red;">mso-pagination:none</span><span style="text-decoration: line-through; color: red;">;</span> <span style="text-decoration: line-through; color: red;">mso-hyphenate:none</span><span style="text-decoration: line-through; color: red;">;</span> <span style="text-decoration: line-through; color: red;">font-size:12.0pt</span><span style="text-decoration: line-through; color: red;">;</span> <span style="text-decoration: line-through; color: red;">font-family</span><span style="text-decoration: line-through; color: red;">:</span><span style="text-decoration: line-through; color: red;">&quot;Times</span> <span style="text-decoration: line-through; color: red;">New</span> <span style="text-decoration: line-through; color: red;">Roman</span><span style="text-decoration: line-through; color: red;">&quot;,&quot;serif&quot;;</span> <span style="text-decoration: line-through; color: red;">mso-fareast-font-family</span><span style="text-decoration: line-through; color: red;">:</span><span style="text-decoration: line-through; color: red;">&quot;Andale</span> <span style="text-decoration: line-through; color: red;">Sans</span> <span style="text-decoration: line-through; color: red;">UI</span><span style="text-decoration: line-through; color: red;">&quot;;</span> <span style="text-decoration: line-through; color: red;">mso-font-kerning:.5pt</span><span style="text-decoration: line-through; color: red;">;</span> <span style="text-decoration: line-through; color: red;">mso-ansi-language:#00FF</span><span style="text-decoration: line-through; color: red;">;</span> <span style="text-decoration: line-through; color: red;">mso-fareast-language:#00FF;</span><span style="text-decoration: line-through; color: red;">}</span> <span style="text-decoration: line-through; color: red;">.</span><span style="text-decoration: line-through; color: red;">MsoChpDefault</span> <span style="text-decoration: line-through; color: red;">{</span><span style="text-decoration: line-through; color: red;">mso-style-type:export-only;</span> <span style="text-decoration: line-through; color: red;">mso-default-props:yes</span><span style="text-decoration: line-through; color: red;">;</span> <span style="text-decoration: line-through; color: red;">font-size:10.0pt</span><span style="text-decoration: line-through; color: red;">;</span> <span style="text-decoration: line-through; color: red;">mso-ansi-font-size:10.0pt</span><span style="text-decoration: line-through; color: red;">;</span> <span style="text-decoration: line-through; color: red;">mso-bidi-font-size:10.0pt;</span><span style="text-decoration: line-through; color: red;">}</span> <span style="text-decoration: line-through; color: red;">@</span><span style="text-decoration: line-through; color: red;">page</span> <span style="text-decoration: line-through; color: red;">Section1</span> <span style="text-decoration: line-through; color: red;">{</span><span style="text-decoration: line-through; color: red;">size:595.25pt</span> <span style="text-decoration: line-through; color: red;">841.85pt</span><span style="text-decoration: line-through; color: red;">;</span> <span style="text-decoration: line-through; color: red;">margin:56.7pt</span> <span style="text-decoration: line-through; color: red;">56.7pt</span> <span style="text-decoration: line-through; color: red;">56.7pt</span> <span style="text-decoration: line-through; color: red;">56.7pt</span><span style="text-decoration: line-through; color: red;">;</span> <span style="text-decoration: line-through; color: red;">mso-header-margin:.5in</span><span style="text-decoration: line-through; color: red;">;</span> <span style="text-decoration: line-through; color: red;">mso-footer-margin:.5in</span><span style="text-decoration: line-through; color: red;">;</span> <span style="text-decoration: line-through; color: red;">mso-paper-source:0;</span><span style="text-decoration: line-through; color: red;">}</span> <span style="text-decoration: line-through; color: red;">div.Section1</span> <span style="text-decoration: line-through; color: red;">{</span><span style="text-decoration: line-through; color: red;">page:Section1;}</span> <span style="text-decoration: line-through; color: red;">-</span><span style="text-decoration: line-through; color: red;">-</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;/style&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;!--[if</span> <span style="text-decoration: line-through; color: red;">gte</span> <span style="text-decoration: line-through; color: red;">mso</span> <span style="text-decoration: line-through; color: red;">10</span><span style="text-decoration: line-through; color: red;">]</span><span style="text-decoration: line-through; color: red;">&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;style&gt;</span> <span style="text-decoration: line-through; color: red;">/</span><span style="text-decoration: line-through; color: red;">*</span> <span style="text-decoration: line-through; color: red;">Style</span> <span style="text-decoration: line-through; color: red;">Definitions</span> <span style="text-decoration: line-through; color: red;">*</span><span style="text-decoration: line-through; color: red;">/</span> <span style="text-decoration: line-through; color: red;">table.MsoNormalTable</span> <span style="text-decoration: line-through; color: red;">{</span><span style="text-decoration: line-through; color: red;">mso-style-name:</span><span style="text-decoration: line-through; color: red;">&quot;Table</span> <span style="text-decoration: line-through; color: red;">Normal</span><span style="text-decoration: line-through; color: red;">&quot;;</span> <span style="text-decoration: line-through; color: red;">mso-tstyle-rowband-size:0</span><span style="text-decoration: line-through; color: red;">;</span> <span style="text-decoration: line-through; color: red;">mso-tstyle-colband-size:0</span><span style="text-decoration: line-through; color: red;">;</span> <span style="text-decoration: line-through; color: red;">mso-style-noshow:yes</span><span style="text-decoration: line-through; color: red;">;</span> <span style="text-decoration: line-through; color: red;">mso-style-priority:99</span><span style="text-decoration: line-through; color: red;">;</span> <span style="text-decoration: line-through; color: red;">mso-style-qformat:yes</span><span style="text-decoration: line-through; color: red;">;</span> <span style="text-decoration: line-through; color: red;">mso-style-parent</span><span style="text-decoration: line-through; color: red;">:</span><span style="text-decoration: line-through; color: red;">&quot;&quot;;</span> <span style="text-decoration: line-through; color: red;">mso-padding-alt:0in</span> <span style="text-decoration: line-through; color: red;">5.4pt</span> <span style="text-decoration: line-through; color: red;">0in</span> <span style="text-decoration: line-through; color: red;">5.4pt</span><span style="text-decoration: line-through; color: red;">;</span> <span style="text-decoration: line-through; color: red;">mso-para-margin:0in</span><span style="text-decoration: line-through; color: red;">;</span> <span style="text-decoration: line-through; color: red;">mso-para-margin-bottom:.0001pt</span><span style="text-decoration: line-through; color: red;">;</span> <span style="text-decoration: line-through; color: red;">mso-pagination:widow-orphan</span><span style="text-decoration: line-through; color: red;">;</span> <span style="text-decoration: line-through; color: red;">font-size:11.0pt</span><span style="text-decoration: line-through; color: red;">;</span> <span style="text-decoration: line-through; color: red;">font-family</span><span style="text-decoration: line-through; color: red;">:</span><span style="text-decoration: line-through; color: red;">&quot;Calibri&quot;,&quot;sans-serif&quot;;</span> <span style="text-decoration: line-through; color: red;">mso-ascii-font-family:Calibri</span><span style="text-decoration: line-through; color: red;">;</span> <span style="text-decoration: line-through; color: red;">mso-ascii-theme-font:minor-latin</span><span style="text-decoration: line-through; color: red;">;</span> <span style="text-decoration: line-through; color: red;">mso-fareast-font-family:SimSun</span><span style="text-decoration: line-through; color: red;">;</span> <span style="text-decoration: line-through; color: red;">mso-fareast-theme-font:minor-fareast</span><span style="text-decoration: line-through; color: red;">;</span> <span style="text-decoration: line-through; color: red;">mso-hansi-font-family:Calibri</span><span style="text-decoration: line-through; color: red;">;</span> <span style="text-decoration: line-through; color: red;">mso-hansi-theme-font:minor-latin</span><span style="text-decoration: line-through; color: red;">;</span> <span style="text-decoration: line-through; color: red;">mso-bidi-font-family</span><span style="text-decoration: line-through; color: red;">:</span><span style="text-decoration: line-through; color: red;">&quot;Times</span> <span style="text-decoration: line-through; color: red;">New</span> <span style="text-decoration: line-through; color: red;">Roman</span><span style="text-decoration: line-through; color: red;">&quot;;</span> <span style="text-decoration: line-through; color: red;">mso-bidi-theme-font:minor-bidi;</span><span style="text-decoration: line-through; color: red;">}</span> <span style="text-decoration: line-through; color: red;">&lt;/style&gt;</span> <span style="text-decoration: line-through; color: red;">&lt;![endif]--&gt;</span> <p class="MsoNormal"><span><span style="text-decoration: line-through; color: red;">Image</span> <span style="text-decoration: line-through; color: red;">charge</span> <span style="text-decoration: line-through; color: red;">effect</span> <span style="text-decoration: line-through; color: red;">comes</span> <span style="text-decoration: line-through; color: red;">from</span> <span style="text-decoration: line-through; color: red;">the</span> <span style="text-decoration: line-through; color: red;">image</span> <span style="text-decoration: line-through; color: red;">charge</span> <span style="text-decoration: line-through; color: red;">method</span><span style="text-decoration: line-through; color: red;">,</span> <span style="text-decoration: line-through; color: red;">which</span> <span style="text-decoration: line-through; color: red;">is</span> <span style="text-decoration: line-through; color: red;">a</span> <span style="text-decoration: line-through; color: red;">general</span> <span style="text-decoration: line-through; color: red;">way</span> <span style="text-decoration: line-through; color: red;">to</span> <span style="text-decoration: line-through; color: red;">simplify</span> <span style="text-decoration: line-through; color: red;">the</span> <span style="text-decoration: line-through; color: red;">calculation</span> <span style="text-decoration: line-through; color: red;">of</span> <span style="text-decoration: line-through; color: red;">the</span> <span style="text-decoration: line-through; color: red;">interaction</span> <span style="text-decoration: line-through; color: red;">between</span> <span style="text-decoration: line-through; color: red;">a</span> <span style="text-decoration: line-through; color: red;">charge</span> <span style="text-decoration: line-through; color: red;">and</span> <span style="text-decoration: line-through; color: red;">a</span> <span style="text-decoration: line-through; color: red;">dielectric</span> <span style="text-decoration: line-through; color: red;">interface</span> <span style="text-decoration: line-through; color: red;">or</span> <span style="text-decoration: line-through; color: red;">a</span> <span style="text-decoration: line-through; color: red;">conductor</span><span style="text-decoration: line-through; color: red;">,</span> <span style="text-decoration: line-through; color: red;">on</span> <span style="text-decoration: line-through; color: red;">the</span> <span style="text-decoration: line-through; color: red;">basis</span> <span style="text-decoration: line-through; color: red;">of</span> <span style="text-decoration: line-through; color: red;">the</span> <span style="text-decoration: line-through; color: red;">&quot;uniqueness</span> <span style="text-decoration: line-through; color: red;">theorem</span><span style="text-decoration: line-through; color: red;">&quot;</span> <span style="text-decoration: line-through; color: red;">[</span><span style="text-decoration: line-through; color: red;">1].</span><span style="text-decoration: line-through; color: red;">&lt;o:p&gt;&lt;/o:p&gt;</span></span></p> <p class="MsoNormal"><span><span style="text-decoration: line-through; color: red;">&lt;o:p&gt;&nbsp;&lt;/o:p&gt;</span></span></p> <p class="MsoNormal"><span><span style="text-decoration: line-through; color: red;">I</span><span style="text-decoration: line-through; color: red;">.</span> <span style="text-decoration: line-through; color: red;">image</span> <span style="text-decoration: line-through; color: red;">charge</span> <span style="text-decoration: line-through; color: red;">effects</span> <span style="text-decoration: line-through; color: red;">due</span> <span style="text-decoration: line-through; color: red;">to</span> <span style="text-decoration: line-through; color: red;">the</span> <span style="text-decoration: line-through; color: red;">dielectric</span> <span style="text-decoration: line-through; color: red;">interface</span><span style="text-decoration: line-through; color: red;">&lt;o:p&gt;&lt;/o:p&gt;</span></span></p> <p class="MsoNormal"><span><span>&nbsp;&nbsp; </span><span style="text-decoration: line-through; color: red;">The</span> <span style="text-decoration: line-through; color: red;">resulting</span> <span style="text-decoration: line-through; color: red;">effects</span> <span style="text-decoration: line-through; color: red;">of</span> <span style="text-decoration: line-through; color: red;">the</span> <span style="text-decoration: line-through; color: red;">presence</span> <span style="text-decoration: line-through; color: red;">of</span> <span style="text-decoration: line-through; color: red;">a</span> <span style="text-decoration: line-through; color: red;">dielectric</span> <span style="text-decoration: line-through; color: red;">interface</span> <span style="text-decoration: line-through; color: red;">are</span> <span style="text-decoration: line-through; color: red;">the</span> <span style="text-decoration: line-through; color: red;">following</span><span style="text-decoration: line-through; color: red;">:</span><span style="text-decoration: line-through; color: red;">&lt;o:p&gt;&lt;/o:p&gt;</span></span></p> <p class="MsoNormal"><span><span style="text-decoration: line-through; color: red;">Imagine</span> <span style="text-decoration: line-through; color: red;">a</span> <span style="text-decoration: line-through; color: red;">water-oil</span> <span style="text-decoration: line-through; color: red;">interface</span><span style="text-decoration: line-through; color: red;">,</span><span style="text-decoration: line-through; color: red;">&lt;o:p&gt;&lt;/o:p&gt;</span></span></p> <p class="MsoNormal"><span><span>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </span><span style="text-decoration: line-through; color: red;">1</span><span style="text-decoration: line-through; color: red;">.</span> <span style="text-decoration: line-through; color: red;">If</span> <span style="text-decoration: line-through; color: red;">a</span> <span style="text-decoration: line-through; color: red;">charge</span> <span style="text-decoration: line-through; color: red;">is</span> <span style="text-decoration: line-through; color: red;">put</span> <span style="text-decoration: line-through; color: red;">in</span> <span style="text-decoration: line-through; color: red;">the</span> <span style="text-decoration: line-through; color: red;">high</span> <span style="text-decoration: line-through; color: red;">dielectric</span> <span style="text-decoration: line-through; color: red;">phase</span> <span style="text-decoration: line-through; color: red;">(</span><span style="text-decoration: line-through; color: red;">water),</span> <span style="text-decoration: line-through; color: red;">then</span> <span style="text-decoration: line-through; color: red;">the</span> <span style="text-decoration: line-through; color: red;">charge</span> <span style="text-decoration: line-through; color: red;">experiences</span> <span style="text-decoration: line-through; color: red;">a</span> <span style="text-decoration: line-through; color: red;">repulsive</span> <span style="text-decoration: line-through; color: red;">force</span> <span style="text-decoration: line-through; color: red;">from</span> <span style="text-decoration: line-through; color: red;">the</span> <span style="text-decoration: line-through; color: red;">dielectric</span> <span style="text-decoration: line-through; color: red;">boundary</span><span style="text-decoration: line-through; color: red;">.</span><span style="text-decoration: line-through; color: red;">&lt;o:p&gt;&lt;/o:p&gt;</span></span></p> <p class="MsoNormal"><span><span>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </span><span style="text-decoration: line-through; color: red;">2</span><span style="text-decoration: line-through; color: red;">.</span> <span style="text-decoration: line-through; color: red;">If</span> <span style="text-decoration: line-through; color: red;">a</span> <span style="text-decoration: line-through; color: red;">charge</span> <span style="text-decoration: line-through; color: red;">is</span> <span style="text-decoration: line-through; color: red;">put</span> <span style="text-decoration: line-through; color: red;">in</span> <span style="text-decoration: line-through; color: red;">the</span> <span style="text-decoration: line-through; color: red;">low</span> <span style="text-decoration: line-through; color: red;">dielectric</span> <span style="text-decoration: line-through; color: red;">phase</span> <span style="text-decoration: line-through; color: red;">(</span><span style="text-decoration: line-through; color: red;">oil),</span> <span style="text-decoration: line-through; color: red;">then</span> <span style="text-decoration: line-through; color: red;">the</span> <span style="text-decoration: line-through; color: red;">charge</span> <span style="text-decoration: line-through; color: red;">experiences</span> <span style="text-decoration: line-through; color: red;">an</span> <span style="text-decoration: line-through; color: red;">attractive</span> <span style="text-decoration: line-through; color: red;">force</span> <span style="text-decoration: line-through; color: red;">from</span> <span style="text-decoration: line-through; color: red;">the</span> <span style="text-decoration: line-through; color: red;">interface</span><span style="text-decoration: line-through; color: red;">.</span> <span style="text-decoration: line-through; color: red;">&lt;o:p&gt;&lt;/o:p&gt;</span></span></p> <p class="MsoNormal"><span><span style="text-decoration: line-through; color: red;">&lt;o:p&gt;&nbsp;&lt;/o:p&gt;</span></span></p> <p class="MsoNormal"><span><span style="text-decoration: line-through; color: red;">II</span><span style="text-decoration: line-through; color: red;">.</span> <span style="text-decoration: line-through; color: red;">image</span> <span style="text-decoration: line-through; color: red;">charge</span> <span style="text-decoration: line-through; color: red;">effects</span> <span style="text-decoration: line-through; color: red;">due</span> <span style="text-decoration: line-through; color: red;">to</span> <span style="text-decoration: line-through; color: red;">a</span> <span style="text-decoration: line-through; color: red;">conductor</span> <span style="text-decoration: line-through; color: red;">surface</span><span style="text-decoration: line-through; color: red;">&lt;o:p&gt;&lt;/o:p&gt;</span></span></p> <p class="MsoNormal"><span><span>&nbsp;&nbsp;&nbsp;&nbsp; </span><span style="text-decoration: line-through; color: red;">Because</span> <span style="text-decoration: line-through; color: red;">of</span> <span style="text-decoration: line-through; color: red;">the</span> <span style="text-decoration: line-through; color: red;">restraint</span> <span style="text-decoration: line-through; color: red;">that</span> <span style="text-decoration: line-through; color: red;">the</span> <span style="text-decoration: line-through; color: red;">electric</span> <span style="text-decoration: line-through; color: red;">field</span> <span style="text-decoration: line-through; color: red;">lines</span> <span style="text-decoration: line-through; color: red;">have</span> <span style="text-decoration: line-through; color: red;">to</span> <span style="text-decoration: line-through; color: red;">be</span> <span style="text-decoration: line-through; color: red;">always</span> <span style="text-decoration: line-through; color: red;">perpendicular</span> <span style="text-decoration: line-through; color: red;">to</span> <span style="text-decoration: line-through; color: red;">the</span> <span style="text-decoration: line-through; color: red;">conductor</span> <span style="text-decoration: line-through; color: red;">surface</span><span style="text-decoration: line-through; color: red;">,</span> <span style="text-decoration: line-through; color: red;">the</span> <span style="text-decoration: line-through; color: red;">image</span> <span style="text-decoration: line-through; color: red;">charge</span> <span style="text-decoration: line-through; color: red;">is</span> <span style="text-decoration: line-through; color: red;">always</span> <span style="text-decoration: line-through; color: red;">of</span> <span style="text-decoration: line-through; color: red;">the</span> <span style="text-decoration: line-through; color: red;">opposite</span> <span style="text-decoration: line-through; color: red;">sign</span> <span style="text-decoration: line-through; color: red;">of</span> <span style="text-decoration: line-through; color: red;">the</span> <span style="text-decoration: line-through; color: red;">original</span> <span style="text-decoration: line-through; color: red;">charge</span><span style="text-decoration: line-through; color: red;">.</span> <span style="text-decoration: line-through; color: red;">&lt;o:p&gt;&lt;/o:p&gt;</span></span></p> <p class="MsoNormal"><span><span style="text-decoration: line-through; color: red;">&lt;o:p&gt;&nbsp;&lt;/o:p&gt;</span></span></p> <p class="MsoNormal"><span><span style="text-decoration: line-through; color: red;">Applications</span><span style="text-decoration: line-through; color: red;">:</span><span style="text-decoration: line-through; color: red;">&lt;o:p&gt;&lt;/o:p&gt;</span></span></p> <p class="MsoNormal"><span><span>&nbsp;&nbsp; </span><span style="text-decoration: line-through; color: red;">The</span> <span style="text-decoration: line-through; color: red;">image</span> <span style="text-decoration: line-through; color: red;">charge</span> <span style="text-decoration: line-through; color: red;">effect</span> <span style="text-decoration: line-through; color: red;">can</span> <span style="text-decoration: line-through; color: red;">be</span> <span style="text-decoration: line-through; color: red;">conveniently</span> <span style="text-decoration: line-through; color: red;">used</span> <span style="text-decoration: line-through; color: red;">to</span> <span style="text-decoration: line-through; color: red;">explain</span> <span style="text-decoration: line-through; color: red;">many</span> <span style="text-decoration: line-through; color: red;">phenomenas</span><span style="text-decoration: line-through; color: red;">.</span> <span style="text-decoration: line-through; color: red;">One</span> <span style="text-decoration: line-through; color: red;">of</span> <span style="text-decoration: line-through; color: red;">them</span> <span style="text-decoration: line-through; color: red;">is</span> <span style="text-decoration: line-through; color: red;">the</span> <span style="text-decoration: line-through; color: red;">pKa</span> <span style="text-decoration: line-through; color: red;">shift</span> <span style="text-decoration: line-through; color: red;">of</span> <span style="text-decoration: line-through; color: red;">an</span> <span style="text-decoration: line-through; color: red;">ionizable</span> <span style="text-decoration: line-through; color: red;">probe</span> <span style="text-decoration: line-through; color: red;">near</span> <span style="text-decoration: line-through; color: red;">the</span> <span style="text-decoration: line-through; color: red;">water-oil</span> <span style="text-decoration: line-through; color: red;">boundary</span> <span style="text-decoration: line-through; color: red;">of</span> <span style="text-decoration: line-through; color: red;">the</span> <span style="text-decoration: line-through; color: red;">micelles</span> <span style="text-decoration: line-through; color: red;">[</span><span style="text-decoration: line-through; color: red;">2].</span><span style="text-decoration: line-through; color: red;">&lt;o:p&gt;&lt;/o:p&gt;</span></span></p> <p class="MsoNormal"><span><span style="text-decoration: line-through; color: red;">&lt;o:p&gt;&nbsp;&lt;/o:p&gt;</span></span></p> <p class="MsoNormal"><span><span style="text-decoration: line-through; color: red;">References</span><span style="text-decoration: line-through; color: red;">:</span><span style="text-decoration: line-through; color: red;">&lt;o:p&gt;&lt;/o:p&gt;</span></span></p> <p class="MsoNormal"><span><span style="text-decoration: line-through; color: red;">1</span><span style="text-decoration: line-through; color: red;">.</span> <span style="text-decoration: line-through; color: red;">Ken</span> <span style="text-decoration: line-through; color: red;">A</span><span style="text-decoration: line-through; color: red;">.</span> <span style="text-decoration: line-through; color: red;">Dill</span> <span style="text-decoration: line-through; color: red;">and</span> <span style="text-decoration: line-through; color: red;">Sarina</span> <span style="text-decoration: line-through; color: red;">Bromberg</span><span style="text-decoration: line-through; color: red;">.</span> <i><span style="text-decoration: line-through; color: red;">Molecular</span> <span style="text-decoration: line-through; color: red;">Driving</span> <span style="text-decoration: line-through; color: red;">Forces</span></i><span style="text-decoration: line-through; color: red;">.</span> <span style="text-decoration: line-through; color: red;">Garland</span> <span style="text-decoration: line-through; color: red;">Science</span><span style="text-decoration: line-through; color: red;">,</span> <span style="text-decoration: line-through; color: red;">New</span> <span style="text-decoration: line-through; color: red;">York</span> <span style="text-decoration: line-through; color: red;">and</span> <span style="text-decoration: line-through; color: red;">London</span><span style="text-decoration: line-through; color: red;">,</span> <span style="text-decoration: line-through; color: red;">2003</span><span style="text-decoration: line-through; color: red;">,</span> <span style="text-decoration: line-through; color: red;">p399-406</span><span style="text-decoration: line-through; color: red;">.</span><span style="text-decoration: line-through; color: red;">&lt;o:p&gt;&lt;/o:p&gt;</span></span></p> <p class="MsoNormal"><span lang="FR"><span style="text-decoration: line-through; color: red;">2</span><span style="text-decoration: line-through; color: red;">.</span> <span style="text-decoration: line-through; color: red;">Soderman</span> <span style="text-decoration: line-through; color: red;">et</span> <span style="text-decoration: line-through; color: red;">al</span><span style="text-decoration: line-through; color: red;">.</span> <span style="text-decoration: line-through; color: red;">J</span><span style="text-decoration: line-through; color: red;">.</span> <span style="text-decoration: line-through; color: red;">Phys</span><span style="text-decoration: line-through; color: red;">.</span> <span style="text-decoration: line-through; color: red;">Chem</span><span style="text-decoration: line-through; color: red;">.</span> <span style="text-decoration: line-through; color: red;">B</span><span style="text-decoration: line-through; color: red;">.</span> <span style="text-decoration: line-through; color: red;">2006</span><span style="text-decoration: line-through; color: red;">,</span> <span style="text-decoration: line-through; color: red;">110</span><span style="text-decoration: line-through; color: red;">,</span> <span style="text-decoration: line-through; color: red;">3288</span><span style="text-decoration: line-through; color: red;">.</span><span style="text-decoration: line-through; color: red;">&lt;o:p&gt;&lt;/o:p&gt;</span></p>http://computchem.org/cs/wikis/computchem/image-charge-effect/revision/1.aspxTue, 09 Mar 2010 18:00:39 GMT1b863b40-6314-48da-8368-fb96d4c4a8e3:59StevenWangRevision 1 posted to Computational Chemistry and Biophysics Wiki by StevenWang on 3/9/2010 12:00:39 PM<br /> <p> &lt;meta http-equiv=&quot;Content-Type&quot; content=&quot;text/html; charset=utf-8&quot; /&gt; &lt;meta name=&quot;ProgId&quot; content=&quot;Word.Document&quot; /&gt; &lt;meta name=&quot;Generator&quot; content=&quot;Microsoft Word 12&quot; /&gt; &lt;meta name=&quot;Originator&quot; content=&quot;Microsoft Word 12&quot; /&gt; &lt;link rel=&quot;File-List&quot; href=&quot;file:///C:\Users\Steven\AppData\Local\Temp\msohtmlclip1\01\clip_filelist.xml&quot; /&gt; &lt;link rel=&quot;Preview&quot; href=&quot;file:///C:\Users\Steven\AppData\Local\Temp\msohtmlclip1\01\clip_preview.wmf&quot; /&gt; &lt;!--[if gte mso 9]&gt;&lt;xml&gt; &lt;o:DocumentProperties&gt; &lt;o:Version&gt;12.00&lt;/o:Version&gt; &lt;/o:DocumentProperties&gt; &lt;/xml&gt;&lt;![endif]--&gt; &lt;link rel=&quot;themeData&quot; href=&quot;file:///C:\Users\Steven\AppData\Local\Temp\msohtmlclip1\01\clip_themedata.thmx&quot; /&gt; &lt;link rel=&quot;colorSchemeMapping&quot; href=&quot;file:///C:\Users\Steven\AppData\Local\Temp\msohtmlclip1\01\clip_colorschememapping.xml&quot; /&gt; &lt;!--[if gte mso 9]&gt;&lt;xml&gt; &lt;w:WordDocument&gt; &lt;w:View&gt;Normal&lt;/w:View&gt; &lt;w:Zoom&gt;0&lt;/w:Zoom&gt; &lt;w:TrackMoves /&gt; &lt;w:TrackFormatting /&gt; &lt;w:PunctuationKerning /&gt; &lt;w:ValidateAgainstSchemas /&gt; &lt;w:SaveIfXMLInvalid&gt;false&lt;/w:SaveIfXMLInvalid&gt; &lt;w:IgnoreMixedContent&gt;false&lt;/w:IgnoreMixedContent&gt; &lt;w:AlwaysShowPlaceholderText&gt;false&lt;/w:AlwaysShowPlaceholderText&gt; &lt;w:DoNotPromoteQF /&gt; &lt;w:LidThemeOther&gt;EN-US&lt;/w:LidThemeOther&gt; &lt;w:LidThemeAsian&gt;ZH-CN&lt;/w:LidThemeAsian&gt; &lt;w:LidThemeComplexScript&gt;X-NONE&lt;/w:LidThemeComplexScript&gt; &lt;w:Compatibility&gt; &lt;w:BreakWrappedTables /&gt; &lt;w:SnapToGridInCell /&gt; &lt;w:WrapTextWithPunct /&gt; &lt;w:UseAsianBreakRules /&gt; &lt;w:DontGrowAutofit /&gt; &lt;w:SplitPgBreakAndParaMark /&gt; &lt;w:DontVertAlignCellWithSp /&gt; &lt;w:DontBreakConstrainedForcedTables /&gt; &lt;w:DontVertAlignInTxbx /&gt; &lt;w:Word11KerningPairs /&gt; &lt;w:CachedColBalance /&gt; &lt;/w:Compatibility&gt; &lt;w:BrowserLevel&gt;MicrosoftInternetExplorer4&lt;/w:BrowserLevel&gt; &lt;m:mathPr&gt; &lt;m:mathFont m:val=&quot;Cambria Math&quot; /&gt; &lt;m:brkBin m:val=&quot;before&quot; /&gt; &lt;m:brkBinSub m:val=&quot;&amp;#45;-&quot; /&gt; &lt;m:smallFrac m:val=&quot;off&quot; /&gt; &lt;m:dispDef /&gt; &lt;m:lMargin m:val=&quot;0&quot; /&gt; &lt;m:rMargin m:val=&quot;0&quot; /&gt; &lt;m:defJc m:val=&quot;centerGroup&quot; /&gt; &lt;m:wrapIndent m:val=&quot;1440&quot; /&gt; &lt;m:intLim m:val=&quot;subSup&quot; /&gt; &lt;m:naryLim m:val=&quot;undOvr&quot; /&gt; &lt;/m:mathPr&gt;&lt;/w:WordDocument&gt; &lt;/xml&gt;&lt;![endif]--&gt;&lt;!--[if gte mso 9]&gt;&lt;xml&gt; &lt;w:LatentStyles DefLockedState=&quot;false&quot; DefUnhideWhenUsed=&quot;true&quot; DefSemiHidden=&quot;true&quot; DefQFormat=&quot;false&quot; DefPriority=&quot;99&quot; LatentStyleCount=&quot;267&quot;&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;0&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; QFormat=&quot;true&quot; Name=&quot;Normal&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;9&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; QFormat=&quot;true&quot; Name=&quot;heading 1&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;9&quot; QFormat=&quot;true&quot; Name=&quot;heading 2&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;9&quot; QFormat=&quot;true&quot; Name=&quot;heading 3&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;9&quot; QFormat=&quot;true&quot; Name=&quot;heading 4&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;9&quot; QFormat=&quot;true&quot; Name=&quot;heading 5&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;9&quot; QFormat=&quot;true&quot; Name=&quot;heading 6&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;9&quot; QFormat=&quot;true&quot; Name=&quot;heading 7&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;9&quot; QFormat=&quot;true&quot; Name=&quot;heading 8&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;9&quot; QFormat=&quot;true&quot; Name=&quot;heading 9&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;39&quot; Name=&quot;toc 1&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;39&quot; Name=&quot;toc 2&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;39&quot; Name=&quot;toc 3&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;39&quot; Name=&quot;toc 4&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;39&quot; Name=&quot;toc 5&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;39&quot; Name=&quot;toc 6&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;39&quot; Name=&quot;toc 7&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;39&quot; Name=&quot;toc 8&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;39&quot; Name=&quot;toc 9&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;35&quot; QFormat=&quot;true&quot; Name=&quot;caption&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;10&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; QFormat=&quot;true&quot; Name=&quot;Title&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;1&quot; Name=&quot;Default Paragraph Font&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;11&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; QFormat=&quot;true&quot; Name=&quot;Subtitle&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;22&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; QFormat=&quot;true&quot; Name=&quot;Strong&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;20&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; QFormat=&quot;true&quot; Name=&quot;Emphasis&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;59&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Table Grid&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Placeholder Text&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;1&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; QFormat=&quot;true&quot; Name=&quot;No Spacing&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;60&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Light Shading&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;61&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Light List&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;62&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Light Grid&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;63&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Medium Shading 1&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;64&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Medium Shading 2&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;65&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Medium List 1&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;66&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Medium List 2&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;67&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Medium Grid 1&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;68&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Medium Grid 2&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;69&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Medium Grid 3&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;70&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Dark List&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;71&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Colorful Shading&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;72&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Colorful List&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;73&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Colorful Grid&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;60&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Light Shading Accent 1&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;61&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Light List Accent 1&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;62&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Light Grid Accent 1&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;63&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Medium Shading 1 Accent 1&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;64&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Medium Shading 2 Accent 1&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;65&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Medium List 1 Accent 1&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Revision&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;34&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; QFormat=&quot;true&quot; Name=&quot;List Paragraph&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;29&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; QFormat=&quot;true&quot; Name=&quot;Quote&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;30&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; QFormat=&quot;true&quot; Name=&quot;Intense Quote&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;66&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Medium List 2 Accent 1&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;67&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Medium Grid 1 Accent 1&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;68&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Medium Grid 2 Accent 1&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;69&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Medium Grid 3 Accent 1&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;70&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Dark List Accent 1&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;71&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Colorful Shading Accent 1&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;72&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Colorful List Accent 1&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;73&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Colorful Grid Accent 1&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;60&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Light Shading Accent 2&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;61&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Light List Accent 2&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;62&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Light Grid Accent 2&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;63&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Medium Shading 1 Accent 2&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;64&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Medium Shading 2 Accent 2&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;65&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Medium List 1 Accent 2&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;66&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Medium List 2 Accent 2&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;67&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Medium Grid 1 Accent 2&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;68&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Medium Grid 2 Accent 2&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;69&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Medium Grid 3 Accent 2&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;70&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Dark List Accent 2&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;71&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Colorful Shading Accent 2&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;72&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Colorful List Accent 2&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;73&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Colorful Grid Accent 2&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;60&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Light Shading Accent 3&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;61&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Light List Accent 3&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;62&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Light Grid Accent 3&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;63&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Medium Shading 1 Accent 3&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;64&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Medium Shading 2 Accent 3&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;65&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Medium List 1 Accent 3&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;66&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Medium List 2 Accent 3&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;67&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Medium Grid 1 Accent 3&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;68&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Medium Grid 2 Accent 3&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;69&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Medium Grid 3 Accent 3&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;70&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Dark List Accent 3&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;71&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Colorful Shading Accent 3&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;72&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Colorful List Accent 3&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;73&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Colorful Grid Accent 3&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;60&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Light Shading Accent 4&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;61&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Light List Accent 4&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;62&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Light Grid Accent 4&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;63&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Medium Shading 1 Accent 4&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;64&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Medium Shading 2 Accent 4&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;65&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Medium List 1 Accent 4&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;66&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Medium List 2 Accent 4&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;67&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Medium Grid 1 Accent 4&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;68&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Medium Grid 2 Accent 4&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;69&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Medium Grid 3 Accent 4&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;70&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Dark List Accent 4&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;71&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Colorful Shading Accent 4&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;72&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Colorful List Accent 4&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;73&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Colorful Grid Accent 4&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;60&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Light Shading Accent 5&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;61&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Light List Accent 5&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;62&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Light Grid Accent 5&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;63&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Medium Shading 1 Accent 5&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;64&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Medium Shading 2 Accent 5&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;65&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Medium List 1 Accent 5&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;66&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Medium List 2 Accent 5&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;67&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Medium Grid 1 Accent 5&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;68&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Medium Grid 2 Accent 5&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;69&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Medium Grid 3 Accent 5&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;70&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Dark List Accent 5&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;71&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Colorful Shading Accent 5&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;72&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Colorful List Accent 5&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;73&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Colorful Grid Accent 5&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;60&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Light Shading Accent 6&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;61&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Light List Accent 6&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;62&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Light Grid Accent 6&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;63&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Medium Shading 1 Accent 6&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;64&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Medium Shading 2 Accent 6&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;65&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Medium List 1 Accent 6&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;66&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Medium List 2 Accent 6&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;67&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Medium Grid 1 Accent 6&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;68&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Medium Grid 2 Accent 6&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;69&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Medium Grid 3 Accent 6&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;70&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Dark List Accent 6&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;71&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Colorful Shading Accent 6&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;72&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Colorful List Accent 6&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;73&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; Name=&quot;Colorful Grid Accent 6&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;19&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; QFormat=&quot;true&quot; Name=&quot;Subtle Emphasis&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;21&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; QFormat=&quot;true&quot; Name=&quot;Intense Emphasis&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;31&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; QFormat=&quot;true&quot; Name=&quot;Subtle Reference&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;32&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; QFormat=&quot;true&quot; Name=&quot;Intense Reference&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;33&quot; SemiHidden=&quot;false&quot; UnhideWhenUsed=&quot;false&quot; QFormat=&quot;true&quot; Name=&quot;Book Title&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;37&quot; Name=&quot;Bibliography&quot; /&gt; &lt;w:LsdException Locked=&quot;false&quot; Priority=&quot;39&quot; QFormat=&quot;true&quot; Name=&quot;TOC Heading&quot; /&gt; &lt;/w:LatentStyles&gt; &lt;/xml&gt;&lt;![endif]--&gt; &lt;style&gt; &lt;!-- /* Font Definitions */ @font-face {font-family:&quot;Cambria Math&quot;; panose-1:2 4 5 3 5 4 6 3 2 4; mso-font-charset:0; mso-generic-font-family:roman; mso-font-pitch:variable; mso-font-signature:-1610611985 1107304683 0 0 159 0;} @font-face {font-family:&quot;Andale Sans UI&quot;; mso-font-alt:&quot;Arial Unicode MS&quot;; mso-font-charset:0; mso-generic-font-family:auto; mso-font-pitch:variable; mso-font-signature:0 0 0 0 0 0;} /* Style Definitions */ p.MsoNormal, li.MsoNormal, div.MsoNormal {mso-style-unhide:no; mso-style-qformat:yes; mso-style-parent:&quot;&quot;; margin:0in; margin-bottom:.0001pt; mso-pagination:none; mso-hyphenate:none; font-size:12.0pt; font-family:&quot;Times New Roman&quot;,&quot;serif&quot;; mso-fareast-font-family:&quot;Andale Sans UI&quot;; mso-font-kerning:.5pt; mso-ansi-language:#00FF; mso-fareast-language:#00FF;} .MsoChpDefault {mso-style-type:export-only; mso-default-props:yes; font-size:10.0pt; mso-ansi-font-size:10.0pt; mso-bidi-font-size:10.0pt;} @page Section1 {size:595.25pt 841.85pt; margin:56.7pt 56.7pt 56.7pt 56.7pt; mso-header-margin:.5in; mso-footer-margin:.5in; mso-paper-source:0;} div.Section1 {page:Section1;} --&gt; &lt;/style&gt; &lt;!--[if gte mso 10]&gt; &lt;style&gt; /* Style Definitions */ table.MsoNormalTable {mso-style-name:&quot;Table Normal&quot;; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:&quot;&quot;; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:&quot;Calibri&quot;,&quot;sans-serif&quot;; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:SimSun; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:&quot;Times New Roman&quot;; mso-bidi-theme-font:minor-bidi;} &lt;/style&gt; &lt;![endif]--&gt; <p class="MsoNormal"><span>Image charge effect comes from the image charge method, which is a general way to simplify the calculation of the interaction between a charge and a dielectric interface or a conductor, on the basis of the &quot;uniqueness theorem&quot; [1].&lt;o:p&gt;&lt;/o:p&gt;</span></p> <p class="MsoNormal"><span>&lt;o:p&gt;&nbsp;&lt;/o:p&gt;</span></p> <p class="MsoNormal"><span>I. image charge effects due to the dielectric interface&lt;o:p&gt;&lt;/o:p&gt;</span></p> <p class="MsoNormal"><span><span>&nbsp;&nbsp; </span>The resulting effects of the presence of a dielectric interface are the following:&lt;o:p&gt;&lt;/o:p&gt;</span></p> <p class="MsoNormal"><span>Imagine a water-oil interface,&lt;o:p&gt;&lt;/o:p&gt;</span></p> <p class="MsoNormal"><span><span>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </span>1. If a charge is put in the high dielectric phase (water), then the charge experiences a repulsive force from the dielectric boundary.&lt;o:p&gt;&lt;/o:p&gt;</span></p> <p class="MsoNormal"><span><span>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </span>2. If a charge is put in the low dielectric phase (oil), then the charge experiences an attractive force from the interface. &lt;o:p&gt;&lt;/o:p&gt;</span></p> <p class="MsoNormal"><span>&lt;o:p&gt;&nbsp;&lt;/o:p&gt;</span></p> <p class="MsoNormal"><span>II. image charge effects due to a conductor surface&lt;o:p&gt;&lt;/o:p&gt;</span></p> <p class="MsoNormal"><span><span>&nbsp;&nbsp;&nbsp;&nbsp; </span>Because of the restraint that the electric field lines have to be always perpendicular to the conductor surface, the image charge is always of the opposite sign of the original charge. &lt;o:p&gt;&lt;/o:p&gt;</span></p> <p class="MsoNormal"><span>&lt;o:p&gt;&nbsp;&lt;/o:p&gt;</span></p> <p class="MsoNormal"><span>Applications:&lt;o:p&gt;&lt;/o:p&gt;</span></p> <p class="MsoNormal"><span><span>&nbsp;&nbsp; </span>The image charge effect can be conveniently used to explain many phenomenas. One of them is the pKa shift of an ionizable probe near the water-oil boundary of the micelles [2].&lt;o:p&gt;&lt;/o:p&gt;</span></p> <p class="MsoNormal"><span>&lt;o:p&gt;&nbsp;&lt;/o:p&gt;</span></p> <p class="MsoNormal"><span>References:&lt;o:p&gt;&lt;/o:p&gt;</span></p> <p class="MsoNormal"><span>1. Ken A. Dill and Sarina Bromberg. <i>Molecular Driving Forces</i>. Garland Science, New York and London, 2003, p399-406.&lt;o:p&gt;&lt;/o:p&gt;</span></p> <p class="MsoNormal"><span lang="FR">2. Soderman et al. J. Phys. Chem. B. 2006, 110, 3288.&lt;o:p&gt;&lt;/o:p&gt;</span></p> </p>http://computchem.org/cs/wikis/computchem/cmap-testing/revision/0.aspxFri, 19 Feb 2010 15:28:01 GMT1b863b40-6314-48da-8368-fb96d4c4a8e3:2JanaCurrent revision posted to Computational Chemistry and Biophysics Wiki by Jana on 2/19/2010 9:28:01 AM<br /> <h2>CMAP testing</h2> <p><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/3162.ala5_5F00_3.pmf.png"><span style="background: SpringGreen;"><img src="/cs/resized-image.ashx/__size/400x0/__key/CommunityServer.Wikis.Components.Files/computchem/3162.ala5_5F00_3.pmf.png" border="0" alt="" /></span></a>&nbsp; </span></span></span></span></p> <h4 class="style8"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">Test the performance of new CHARMM torsion potential for GBSW implicit-solvent simulations</span></span></span></span></span></h4> <p><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span class="style1"><span class="style2">New CMAP (par_mod24_2_6.prm): recently optimized by the Feig group at MSU&nbsp;to correct for the helical bias vs extended regions<br /><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"></span></span></span></span></span></span></span></span></span></span></span></span></p> <p><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span class="style1"><span class="style2"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">par31_2_6: same CMAP as above but with the new force field for alkanes from the MacKerell group at UMBT</span></span></span></span></span></span></span></span></span></span></span></span></p> <p><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span class="style1"><span class="style2"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"></span></span></span></span></span></span> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">par31feigmp2_d1: CMAP optimized based on the&nbsp;MP2 map version 1</span></span></span></span></span></span></span></span></span></span></p> </span>GBSW CMAP (par_all22_prot_gbsw.inp): an analytic function was added to the old CMAP to correct for the helical bias for GBSW implicit-solvent simulations. GBSW CMAP was able to fold both helical and beta-sheet proteins (Chen et al,&nbsp;JACS 2006)</span></span></span></span></span></p> <p>&nbsp;<span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">par31feigmp2_d2: CMAP optimized based on the MP2 map version 2</span></span></span></span></span></span></span></span></span></span></p> <p>&nbsp;</p> <p>Old CMAP (par_all22_prot_cmap.inp): Phi, Psi grid map to correction for overstabilization of pi helix <br />(Feig et al, JPCB 2003, MacKerell et al, JCC 2004, MacKerell et al, JACS 2004)</p> <h4 class="style7"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">Ala dipeptide</span></span></span></span></span></h4> <p><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">20 ns REX-GBSW simulations, data collected in the last 5 ns at 298 K</span></span></span></span></span></p> <p> <table cellpadding="0" cellspacing="0" border="1" class="style16" style="mso-border-alt:solid black .5pt;mso-border-themecolor:text1;mso-yfti-tbllook:1184;mso-padding-alt:0pt 5.4pt 0pt 5.4pt;"> <tbody> <tr style="mso-yfti-irow:0;mso-yfti-firstrow:yes;"> <td width="319" valign="top" class="style13" style="width:239.4pt;"> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">mp2_d1</span></span></span></span></span></span></span></span></span></span></p> </td> <td valign="top" class="style14" style="width:251pt;"> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">mp2_d2</span></span></span></span></span></span></span></span></span></span></p> </td> </tr> <tr style="mso-yfti-irow:1;"> <td width="319" valign="top" class="style15" style="width:239.4pt;"><a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/4274.ala_5F00_new.png"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"></span></span></span></span></span></a> <p class="MsoNormal"><a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/4118.ala.pmf.png"><img src="/cs/resized-image.ashx/__size/400x0/__key/CommunityServer.Wikis.Components.Files/computchem/4118.ala.pmf.png" border="0" alt="" /></a><br /><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span class="style10"><span style="color:#000080;">Comparison to explicit-solvent results: PPII is not enough deep or AlpaR is not enough high.</span></span></span></span></span></span></span></p> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span class="style10"><span style="color:#000080;"><span style="color:#000000;">GBMV</span></span></span></span></span></span></span></span></p> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span class="style10"><span style="color:#000080;"><a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/0841.ala_5F00_gbmv.pmf.png"><img src="/cs/resized-image.ashx/__size/400x0/__key/CommunityServer.Wikis.Components.Files/computchem/0841.ala_5F00_gbmv.pmf.png" border="0" alt="" /></a></span></span></span></span></span></span></span></p> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span class="style10"><span style="color:#000080;">Similar</span></span></span></span></span></span></span></p> </td> <td valign="top" class="style15" style="width:251pt;"><a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/2845.ala_5F00_old.png"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"></span></span></span></span></span></a> <p class="MsoNormal"><a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/2146.ala.pmf.png"></a><a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/3146.ala.pmf.png"><img src="/cs/resized-image.ashx/__size/400x0/__key/CommunityServer.Wikis.Components.Files/computchem/3146.ala.pmf.png" border="0" alt="" /></a><br /><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span class="style10"><span style="color:#000080;"></span></span></span></span></span></span></span></p> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="color:#000080;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span class="style10"><span style="color:#000080;">Even more helical</span></span></span></span></span></span></span></span></span></span></span></span></span></p> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="color:#000080;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="color:#000080;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span class="style10"><span style="color:#000080;"><span style="color:#000000;">GBMV</span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></p> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="color:#000080;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="color:#000080;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span class="style10"><span style="color:#000080;"><span style="color:#000000;"></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/6763.ala_5F00_gbmv.pmf.png"></a><a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/8561.ala_5F00_gbmv.pmf.png"><img src="/cs/resized-image.ashx/__size/400x0/__key/CommunityServer.Wikis.Components.Files/computchem/8561.ala_5F00_gbmv.pmf.png" border="0" alt="" /></a><br />&nbsp;</span></span></span></span></span></span></span></span></span></span><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span class="style10"><span style="color:#000080;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span class="style10"><span style="color:#000080;">Less helical</span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></p> </td> </tr> <tr style="mso-yfti-irow:2;mso-yfti-lastrow:yes;"> <td width="319" valign="top" class="style2" style="width:239.4pt;"> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">&nbsp;</span></span></span></span></span><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"></span></span></span></span></span><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; expt&nbsp;&nbsp;&nbsp; GBSW&nbsp;&nbsp;&nbsp; GBMV</span></span></span></span></span></p> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"></span></span></span></span></span><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">3JHNHa:&nbsp;5.68&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; 5.09&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; 5.67</span></span></span></span></span><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </span></span></span></span></span></p> </td> <td valign="top" class="style2" style="width:251pt;"> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; expt&nbsp;&nbsp;&nbsp; GBSW&nbsp;&nbsp;&nbsp; GBMV</span></span></span></span></span></p> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"></span></span></span></span></span><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">3JHNHa:&nbsp;5.68&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; 5.20&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; 5.64</span></span></span></span></span><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span></span></span></span></span></p> </td> </tr> </tbody> </table> </p> <h4><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span class="style7">Ala3 (free N-ter and protonated C-ter)</span>&nbsp;</span></span></span></span></span></h4> <p><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">20 ns REX-GBSW simulations, data collected in the last 5 ns at 298 K. </span></span></span></span></span><a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/7444.ala3_5F00_2.pp.pmf.png"><br /></a></p> <p> <table cellpadding="0" cellspacing="0" border="1" class="style16" style="mso-border-alt:solid black .5pt;mso-border-themecolor:text1;mso-yfti-tbllook:1184;mso-padding-alt:0pt 5.4pt 0pt 5.4pt;"> <tbody> <tr style="mso-yfti-irow:0;mso-yfti-firstrow:yes;"> <td width="319" valign="top" class="style13" style="width:239.4pt;"> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">&nbsp;<span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">par31feigmp2_d1 </span></span></span></span></span></span></span></span></span></span>residue #2</span></span></span></span></span></p> </td> <td width="319" valign="top" class="style14" style="width:239.4pt;"> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">par31_2_6&nbsp;residue #2</span></span></span></span></span></p> </td> </tr> <tr style="mso-yfti-irow:1;"> <td width="319" valign="top" class="style15" style="width:239.4pt;"> <p class="MsoNormal"><span style="font-family:Calibri;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">&nbsp;<a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/7230.ala3_5F00_2.pmf.png"><img src="/cs/resized-image.ashx/__size/400x0/__key/CommunityServer.Wikis.Components.Files/computchem/7230.ala3_5F00_2.pmf.png" border="0" alt="" /></a></span></span></span></span></span></span><a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/0317.ala3_5F00_2_5F00_new.png"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"></span></span></span></span></span></a><br /><span class="style10"><span style="color:#000080;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">AlphaR is too stable.</span></span></span></span></span></span></span></p> </td> <td width="319" valign="top" class="style15" style="width:239.4pt;"> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">&nbsp; <a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/7343.ala3_5F00_2.pp.pmf.png"><img src="/cs/resized-image.ashx/__size/400x0/__key/CommunityServer.Wikis.Components.Files/computchem/7343.ala3_5F00_2.pp.pmf.png" border="0" alt="" /></a></span></span></span></span></span><a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/4527.ala3_5F00_2_5F00_old.png"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"></span></span></span></span></span></a><br /><span class="style10"><span style="color:#000080;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">Similar to Ala dipep map.&nbsp;Alpha-L is too high&nbsp;as compared to explicit-solvent data&nbsp;(consistent with the ala-dipep map).</span></span></span></span></span></span></span></p> </td> </tr> <tr style="mso-yfti-irow:2;mso-yfti-lastrow:yes;"> <td width="319" valign="top" class="style2" style="width:239.4pt;"> <p class="MsoNormal"><span style="color:#000000;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span class="style1"><span class="style5"><span class="style2">Time averaged NMR coupling <br />&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; simulation&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; expt</span></span></span> </span></span></span></span></span></span></p> <p class="MsoNormal"><span style="font-family:Arial;"><span style="color:#000000;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span class="style1"><span class="style5" style="line-height:115%;mso-ascii-theme-font:minor-latin;mso-fareast-font-family:SimSun;mso-fareast-theme-font:minor-fareast;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:&#39;Times New Roman&#39;;mso-bidi-theme-font:minor-bidi;mso-ansi-language:EN-US;mso-fareast-language:ZH-CN;mso-bidi-language:AR-SA;"><span class="style2">3JHNHa&nbsp; 4.93&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; 5.68<br />3JHNCp&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; 1.13<br />3JHACp&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; 1.84<br />3JCpCp&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp; 0.25<br />3JHNCb&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp;2.39<br />1JNCa&nbsp;&nbsp;&nbsp;&nbsp;11.04&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; 11.34<br />2JNCa&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; 7.92&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; 8.45</span></span></span> <br /><br /><span class="style10">Much better agreement with experiment!</span></span></span></span></span></span></span></span></p> </td> <td width="319" valign="top" class="style2" style="width:239.4pt;"> <p class="MsoNormal"><span class="style1" style="font-family:Calibri;font-size:small;"><span class="style5"><span class="style2"><span style="font-size:x-small;"><span style="color:#000000;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">Time averaged NMR coupling <br />&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; simulation&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span></span></span></span></span></span></span></span></span></span></p> <p class="MsoNormal"><span class="style1" style="font-family:Calibri;font-size:small;"><span class="style5"><span class="style2"><span style="font-size:x-small;"><span style="color:#000000;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="font-family:Arial;"><span style="color:#000000;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span class="style1"><span class="style5" style="line-height:115%;mso-ascii-theme-font:minor-latin;mso-fareast-font-family:SimSun;mso-fareast-theme-font:minor-fareast;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:&#39;Times New Roman&#39;;mso-bidi-theme-font:minor-bidi;mso-ansi-language:EN-US;mso-fareast-language:ZH-CN;mso-bidi-language:AR-SA;"><span class="style2">3JHNHa&nbsp;&nbsp; &nbsp;5.00</span></span></span></span></span></span></span></span></span></span>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </span></span></span></span></span></span></span></span></span></span></p> <p class="MsoNormal"><span class="style1" style="font-family:Calibri;font-size:small;"><span class="style5"><span class="style2"><span style="font-size:x-small;"><span style="color:#000000;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"></span></span></span></span></span></span></span></span></span></span><span class="style1" style="font-family:Calibri;font-size:small;"><span class="style5"><span class="style2"><span style="font-size:x-small;"><span style="color:#000000;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">1JNCa&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp;</span></span></span></span></span></span></span></span></span></span><span class="style1" style="font-family:Calibri;font-size:small;"><span class="style5"><span class="style2"><span style="font-size:x-small;"><span style="color:#000000;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">1.19&nbsp;&nbsp; </span></span></span></span></span></span></span></span></span></span></p> <p class="MsoNormal"><span class="style1" style="font-family:Calibri;font-size:small;"><span class="style5"><span class="style2"><span style="font-size:x-small;"><span style="color:#000000;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"></span></span></span></span></span></span></span></span></span></span><span class="style1" style="font-family:Calibri;font-size:small;"><span class="style5"><span class="style2"><span style="font-size:x-small;"><span style="color:#000000;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">2JNCa&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; 8.18<br />&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </span></span></span></span></span></span></span></span></span></span></p> </td> </tr> </tbody> </table> </p> <p> <p><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">&nbsp;</span></span></span></span></span></p> <h4><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">Ala5 </span></span></span></span></span></h4> <p><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">20 ns REX-GBSW simulations, data collected in the last 5 ns at 295 K</span></span></span></span></span></p> </p> <p> <table cellpadding="0" cellspacing="0" border="1" class="style16" style="mso-border-alt:solid black .5pt;mso-border-themecolor:text1;mso-yfti-tbllook:1184;mso-padding-alt:0pt 5.4pt 0pt 5.4pt;"> <tbody> <tr style="mso-yfti-irow:0;mso-yfti-firstrow:yes;"> <td width="319" valign="top" class="style13" style="width:239.4pt;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">mp2_d1</span></span></span></span></span></span></span></span></span></span>&nbsp;&nbsp;res 2 </p> </span></span></span></span></span></td> <td width="319" valign="top" class="style14" style="width:239.4pt;"> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">&nbsp;<span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">mp2_d1 </span></span></span></span></span></span></span></span></span></span>res 2 (GBMV)</span></span></span></span></span></p> </td> </tr> <tr style="mso-yfti-irow:1;"> <td width="319" valign="top" class="style15" style="width:239.4pt;"> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">&nbsp; <a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/8473.ala5_5F00_2.pp.pmf.png"><img src="/cs/resized-image.ashx/__size/400x0/__key/CommunityServer.Wikis.Components.Files/computchem/8473.ala5_5F00_2.pp.pmf.png" border="0" alt="" /></a></span></span></span></span></span><a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/5314.ala5_5F00_2_5F00_new.png"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"></span></span></span></span></span></a><br /><span class="style11"><br /></span><span class="style10"><span style="color:#000080;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">Same problem as in Ala dipep.</span></span></span></span></span></span></span></p> </td> <td width="319" valign="top" class="style15" style="width:239.4pt;"> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">&nbsp; <a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/6683.ala5_5F00_gbmv_5F00_2.pmf.png"><img src="/cs/resized-image.ashx/__size/400x0/__key/CommunityServer.Wikis.Components.Files/computchem/6683.ala5_5F00_gbmv_5F00_2.pmf.png" border="0" alt="" /></a><a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/6064.ala5_5F00_2.pp.pmf.png"></a></span></span></span></span></span></p> <p class="MsoNormal"><span class="style10"><span style="color:#000080;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">.Alpha-R region is less stable than in GBSW.</span></span></span></span></span></span></span></p> </td> </tr> <tr style="mso-yfti-irow:2;"> <td width="319" valign="top" class="style2" style="width:239.4pt;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">mp2_d1&nbsp;</span></span></span></span></span></span></span></span></span></span></p> </span></span></span></span></span>&nbsp;res 3 </span></span></span></span></span></td> <td width="319" valign="top" class="style2" style="width:239.4pt;"> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">mp2_d1&nbsp;res 3 (GBMV)</span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></p> </td> </tr> <tr style="mso-yfti-irow:3;"> <td width="319" valign="top" class="style2" style="width:239.4pt;"> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">&nbsp; <a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/3718.ala5_5F00_3.pp.pmf.png"><img src="/cs/resized-image.ashx/__size/400x0/__key/CommunityServer.Wikis.Components.Files/computchem/3718.ala5_5F00_3.pp.pmf.png" border="0" alt="" /></a></span></span></span></span></span><a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/0624.ala5_5F00_3_5F00_new.png"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"></span></span></span></span></span></a><br /><br /><span class="style10"><span style="color:#000080;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">AlphaR region is slightly more stabilized. </span></span></span></span></span></span></span></p> </td> <td width="319" valign="top" class="style2" style="width:239.4pt;"> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">&nbsp; <a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/1263.ala5_5F00_gbmv_5F00_3.pmf.png"><img src="/cs/resized-image.ashx/__size/400x0/__key/CommunityServer.Wikis.Components.Files/computchem/1263.ala5_5F00_gbmv_5F00_3.pmf.png" border="0" alt="" /></a><a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/1488.ala5_5F00_3.pp.pmf.png"></a></span></span></span></span></span></p> <p class="MsoNormal"><span class="style10"><span style="color:#000080;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">AlphaR region is less stable than GBSW</span></span></span></span></span></span></span></p> </td> </tr> <tr style="mso-yfti-irow:4;"> <td width="319" valign="top" class="style14" style="width:239.4pt;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">mp2_d1&nbsp;</span></span></span></span></span></span></span></span></span></span>&nbsp;res 4 </p> </span></span></span></span></span></td> <td width="319" valign="top" class="style14" style="width:239.4pt;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">mp2_d1&nbsp;</span></span></span></span></span></span></span></span></span></span>&nbsp;res 4&nbsp;(GBMV)</p> </span></span></span></span></span></span></span></span></span></span></td> </tr> <tr style="mso-yfti-irow:5;"> <td width="319" valign="top" class="style15" style="width:239.4pt;"> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">&nbsp; <a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/0143.ala5_5F00_4.pp.pmf.png"><img src="/cs/resized-image.ashx/__size/400x0/__key/CommunityServer.Wikis.Components.Files/computchem/0143.ala5_5F00_4.pp.pmf.png" border="0" alt="" /></a></span></span></span></span></span><a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/4846.ala5_5F00_4_5F00_new.png"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"></span></span></span></span></span></a><br /><br /><span class="style10"><span style="color:#000080;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">AlphaR region is as stable as PPII region. Helicity is building up as the peptide lengths increases. This has to do with overstabilization of hydrogen bonding in GB.</span></span></span></span></span></span></span></p> </td> <td width="319" valign="top" class="style15" style="width:239.4pt;"> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">&nbsp; <a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/5852.ala5_5F00_gbmv_5F00_4.pmf.png"><img src="/cs/resized-image.ashx/__size/400x0/__key/CommunityServer.Wikis.Components.Files/computchem/5852.ala5_5F00_gbmv_5F00_4.pmf.png" border="0" alt="" /></a><a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/1104.ala5_5F00_4.pp.pmf.png"></a></span></span></span></span></span></p> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span class="style10"><span style="color:#000080;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">AlpahaR region is less stable than GBSW.&nbsp;</span></span></span></span></span></span></span><a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/5187.ala5_5F00_4.pp.pmf.png"></a></span></span></span></span></span></p> <a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/7635.ala5_5F00_4_5F00_old.png"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"></span></span></span></span></span></a></td> </tr> <tr style="mso-yfti-irow:6;mso-yfti-lastrow:yes;"> <td width="319" valign="top" class="style2" style="width:239.4pt;"> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">&nbsp;J-coup&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; res 2&nbsp;expt&nbsp;&nbsp;&nbsp;res 3&nbsp; expt&nbsp;&nbsp;&nbsp;res 4&nbsp; expt</span></span></span></span></span></p> <span class="style2"> <p class="MsoPlainText"><span style="color:#000000;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">3JHNHa&nbsp;&nbsp; 4.97&nbsp;&nbsp;&nbsp;5.59&nbsp;&nbsp;4.98&nbsp;&nbsp;&nbsp;5.74&nbsp; 5.13&nbsp;&nbsp;&nbsp; <span style="background: SpringGreen;">5.98</span><br /></span></span></span></span></span></span></p> </span></td> <td width="319" valign="top" class="style2" style="width:239.4pt;"> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">&nbsp;<span style="background: SpringGreen;">J-coup</span>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <span style="background: SpringGreen;">res</span> <span style="background: SpringGreen;">2</span>&nbsp;&nbsp;<span style="background: SpringGreen;">expt</span>&nbsp; <span style="background: SpringGreen;">res</span> <span style="background: SpringGreen;">3</span>&nbsp;&nbsp;<span style="background: SpringGreen;">expt</span>&nbsp; <span style="background: SpringGreen;">res</span> <span style="background: SpringGreen;">4</span> <span style="background: SpringGreen;">expt</span></span></span></span></span></span></p> <p class="MsoNormal"><span style="font-family:Calibri;font-size:small;"><span class="style1"><span class="style5"><span class="style2"><span style="font-family:Arial;color:#000080;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="color:#000000;"><span style="color:#000000;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="background: SpringGreen;">3JHNHa</span>&nbsp;&nbsp;&nbsp; <span style="background: SpringGreen;">5.27</span>&nbsp;&nbsp;&nbsp;<span style="background: SpringGreen;">5.59</span>&nbsp; <span style="background: SpringGreen;">5.24</span>&nbsp;&nbsp;&nbsp;<span style="background: SpringGreen;">5.74</span>&nbsp;&nbsp;<span style="background: SpringGreen;">5.37</span> <span style="background: SpringGreen;">5.98</span> </span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></p> <p class="MsoNormal"><span style="font-family:Calibri;font-size:small;"><span class="style1"><span class="style5"><span class="style2"><span style="font-family:Arial;color:#000080;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="color:#000000;"><span style="color:#000000;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span><span style="font-family:Calibri;font-size:small;"><span class="style1"><span class="style5"><span class="style2"><span style="font-family:Arial;color:#000080;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="color:#000000;"><span style="color:#000000;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="background: SpringGreen;">GBMV</span> <span style="background: SpringGreen;">gives</span> <span style="background: SpringGreen;">better</span> <span style="background: SpringGreen;">agreement</span> <span style="background: SpringGreen;">with</span> <span style="background: SpringGreen;">expt</span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></p> </td> </tr> </tbody> </table> </p> <h4><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"> <table cellpadding="0" cellspacing="0" border="1" class="style16" style="mso-border-alt:solid black .5pt;mso-border-themecolor:text1;mso-yfti-tbllook:1184;mso-padding-alt:0pt 5.4pt 0pt 5.4pt;"> <tbody> <tr style="mso-yfti-irow:0;mso-yfti-firstrow:yes;"> <td width="319" valign="top" class="style13" style="width:239.4pt;"><span style="font-size:x-small;"><span style="font-family:times new roman, times;"><span style="font-size:small;"><span style="font-family:arial, helvetica, sans-serif;"><span style="font-size:small;"> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman, times;"><span style="font-size:small;"><span style="font-family:arial, helvetica, sans-serif;"><span style="font-size:small;"><span style="font-size:x-small;"><span style="font-family:times new roman, times;"><span style="font-size:small;"><span style="font-family:arial, helvetica, sans-serif;"><span style="font-size:small;"><span style="background: SpringGreen;">mp2_d1</span></span></span></span></span></span></span></span></span></span></span>&nbsp;&nbsp;<span style="background: SpringGreen;">res</span> <span style="background: SpringGreen;">2</span> </p> </span></span></span></span></span></td> <td width="319" valign="top" class="style14" style="width:239.4pt;"> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman, times;"><span style="font-size:small;"><span style="font-family:arial, helvetica, sans-serif;"><span style="font-size:small;">&nbsp;<span style="font-size:x-small;"><span style="font-family:times new roman, times;"><span style="font-size:small;"><span style="font-family:arial, helvetica, sans-serif;"><span style="font-size:small;"><span style="font-size:x-small;"><span style="font-family:times new roman, times;"><span style="font-size:small;"><span style="font-family:arial, helvetica, sans-serif;"><span style="font-size:small;"><span style="background: SpringGreen;">mp2_d1</span> </span></span></span></span></span></span></span></span></span></span><span style="background: SpringGreen;">res</span> <span style="background: SpringGreen;">2</span> <span style="background: SpringGreen;">(</span><span style="background: SpringGreen;">GBMV)</span></span></span></span></span></span></p> </td> </tr> <tr style="mso-yfti-irow:1;"> <td width="319" valign="top" class="style15" style="width:239.4pt;"> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman, times;"><span style="font-size:small;"><span style="font-family:arial, helvetica, sans-serif;"><span style="font-size:small;">&nbsp; <a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/8473.ala5_5F00_2.pp.pmf.png"><span style="background: SpringGreen;"><img src="/cs/resized-image.ashx/__size/400x0/__key/CommunityServer.Wikis.Components.Files/computchem/8473.ala5_5F00_2.pp.pmf.png" border="0" alt="" /></span></a></span></span></span></span></span><a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/5314.ala5_5F00_2_5F00_new.png"><span style="font-size:x-small;"><span style="font-family:times new roman, times;"><span style="font-size:small;"><span style="font-family:arial, helvetica, sans-serif;"><span style="font-size:small;"></span></span></span></span></span></a><br /><span class="style11"><br /></span><span class="style10"><span style="color:#000080;"><span style="font-size:x-small;"><span style="font-family:times new roman, times;"><span style="font-size:small;"><span style="font-family:arial, helvetica, sans-serif;"><span style="font-size:small;"><span style="background: SpringGreen;">Same</span> <span style="background: SpringGreen;">problem</span> <span style="background: SpringGreen;">as</span> <span style="background: SpringGreen;">in</span> <span style="background: SpringGreen;">Ala</span> <span style="background: SpringGreen;">dipep</span><span style="background: SpringGreen;">.</span></span></span></span></span></span></span></span></p> </td> <td width="319" valign="top" class="style15" style="width:239.4pt;"> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman, times;"><span style="font-size:small;"><span style="font-family:arial, helvetica, sans-serif;"><span style="font-size:small;">&nbsp; <a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/6683.ala5_5F00_gbmv_5F00_2.pmf.png"><span style="background: SpringGreen;"><img src="/cs/resized-image.ashx/__size/400x0/__key/CommunityServer.Wikis.Components.Files/computchem/6683.ala5_5F00_gbmv_5F00_2.pmf.png" border="0" alt="" /></span></a><a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/6064.ala5_5F00_2.pp.pmf.png"></a></span></span></span></span></span></p> <p class="MsoNormal"><span class="style10"><span style="color:#000080;"><span style="font-size:x-small;"><span style="font-family:times new roman, times;"><span style="font-size:small;"><span style="font-family:arial, helvetica, sans-serif;"><span style="font-size:small;"><span style="background: SpringGreen;">.</span><span style="background: SpringGreen;">Alpha-R</span> <span style="background: SpringGreen;">region</span> <span style="background: SpringGreen;">is</span> <span style="background: SpringGreen;">less</span> <span style="background: SpringGreen;">stable</span> <span style="background: SpringGreen;">than</span> <span style="background: SpringGreen;">in</span> <span style="background: SpringGreen;">GBSW</span><span style="background: SpringGreen;">.</span></span></span></span></span></span></span></span></p> </td> </tr> <tr style="mso-yfti-irow:2;"> <td width="319" valign="top" class="style2" style="width:239.4pt;"><span style="font-size:x-small;"><span style="font-family:times new roman, times;"><span style="font-size:small;"><span style="font-family:arial, helvetica, sans-serif;"><span style="font-size:small;"><span style="font-size:x-small;"><span style="font-family:times new roman, times;"><span style="font-size:small;"><span style="font-family:arial, helvetica, sans-serif;"><span style="font-size:small;"> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman, times;"><span style="font-size:small;"><span style="font-family:arial, helvetica, sans-serif;"><span style="font-size:small;"><span style="font-size:x-small;"><span style="font-family:times new roman, times;"><span style="font-size:small;"><span style="font-family:arial, helvetica, sans-serif;"><span style="font-size:small;"><span style="background: SpringGreen;">mp2_d1</span>&nbsp;</span></span></span></span></span></span></span></span></span></span></p> </span></span></span></span></span>&nbsp;<span style="background: SpringGreen;">res</span> <span style="background: SpringGreen;">3</span> </span></span></span></span></span></td> <td width="319" valign="top" class="style2" style="width:239.4pt;"> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman, times;"><span style="font-size:small;"><span style="font-family:arial, helvetica, sans-serif;"><span style="font-size:small;"><span style="font-size:x-small;"><span style="font-family:times new roman, times;"><span style="font-size:small;"><span style="font-family:arial, helvetica, sans-serif;"><span style="font-size:small;"><span style="font-size:x-small;"><span style="font-family:times new roman, times;"><span style="font-size:small;"><span style="font-family:arial, helvetica, sans-serif;"><span style="font-size:small;"><span style="font-size:x-small;"><span style="font-family:times new roman, times;"><span style="font-size:small;"><span style="font-family:arial, helvetica, sans-serif;"><span style="font-size:small;"><span style="background: SpringGreen;">mp2_d1</span>&nbsp;<span style="background: SpringGreen;">res</span> <span style="background: SpringGreen;">3</span> <span style="background: SpringGreen;">(</span><span style="background: SpringGreen;">GBMV)</span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></p> </td> </tr> <tr style="mso-yfti-irow:3;"> <td width="319" valign="top" class="style2" style="width:239.4pt;"> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman, times;"><span style="font-size:small;"><span style="font-family:arial, helvetica, sans-serif;"><span style="font-size:small;">&nbsp; <a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/3718.ala5_5F00_3.pp.pmf.png"><span style="background: SpringGreen;"><img src="/cs/resized-image.ashx/__size/400x0/__key/CommunityServer.Wikis.Components.Files/computchem/3718.ala5_5F00_3.pp.pmf.png" border="0" alt="" /></span></a></span></span></span></span></span><a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/0624.ala5_5F00_3_5F00_new.png"><span style="font-size:x-small;"><span style="font-family:times new roman, times;"><span style="font-size:small;"><span style="font-family:arial, helvetica, sans-serif;"><span style="font-size:small;"></span></span></span></span></span></a><br /><br /><span class="style10"><span style="color:#000080;"><span style="font-size:x-small;"><span style="font-family:times new roman, times;"><span style="font-size:small;"><span style="font-family:arial, helvetica, sans-serif;"><span style="font-size:small;"><span style="background: SpringGreen;">AlphaR</span> <span style="background: SpringGreen;">region</span> <span style="background: SpringGreen;">is</span> <span style="background: SpringGreen;">slightly</span> <span style="background: SpringGreen;">more</span> <span style="background: SpringGreen;">stabilized</span><span style="background: SpringGreen;">.</span> </span></span></span></span></span></span></span></p> </td> <td width="319" valign="top" class="style2" style="width:239.4pt;"> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman, times;"><span style="font-size:small;"><span style="font-family:arial, helvetica, sans-serif;"><span style="font-size:small;">&nbsp; <a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/1263.ala5_5F00_gbmv_5F00_3.pmf.png"><span style="background: SpringGreen;"><img src="/cs/resized-image.ashx/__size/400x0/__key/CommunityServer.Wikis.Components.Files/computchem/1263.ala5_5F00_gbmv_5F00_3.pmf.png" border="0" alt="" /></span></a><a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/1488.ala5_5F00_3.pp.pmf.png"></a></span></span></span></span></span></p> <p class="MsoNormal"><span class="style10"><span style="color:#000080;"><span style="font-size:x-small;"><span style="font-family:times new roman, times;"><span style="font-size:small;"><span style="font-family:arial, helvetica, sans-serif;"><span style="font-size:small;"><span style="background: SpringGreen;">AlphaR</span> <span style="background: SpringGreen;">region</span> <span style="background: SpringGreen;">is</span> <span style="background: SpringGreen;">less</span> <span style="background: SpringGreen;">stable</span> <span style="background: SpringGreen;">than</span> <span style="background: SpringGreen;">GBSW</span></span></span></span></span></span></span></span></p> </td> </tr> <tr style="mso-yfti-irow:4;"> <td width="319" valign="top" class="style14" style="width:239.4pt;"><span style="font-size:x-small;"><span style="font-family:times new roman, times;"><span style="font-size:small;"><span style="font-family:arial, helvetica, sans-serif;"><span style="font-size:small;"> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman, times;"><span style="font-size:small;"><span style="font-family:arial, helvetica, sans-serif;"><span style="font-size:small;"><span style="font-size:x-small;"><span style="font-family:times new roman, times;"><span style="font-size:small;"><span style="font-family:arial, helvetica, sans-serif;"><span style="font-size:small;"><span style="background: SpringGreen;">mp2_d1</span>&nbsp;</span></span></span></span></span></span></span></span></span></span>&nbsp;<span style="background: SpringGreen;">res</span> <span style="background: SpringGreen;">4</span> </p> </span></span></span></span></span></td> <td width="319" valign="top" class="style14" style="width:239.4pt;"><span style="font-size:x-small;"><span style="font-family:times new roman, times;"><span style="font-size:small;"><span style="font-family:arial, helvetica, sans-serif;"><span style="font-size:small;"><span style="font-size:x-small;"><span style="font-family:times new roman, times;"><span style="font-size:small;"><span style="font-family:arial, helvetica, sans-serif;"><span style="font-size:small;"> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman, times;"><span style="font-size:small;"><span style="font-family:arial, helvetica, sans-serif;"><span style="font-size:small;"><span style="font-size:x-small;"><span style="font-family:times new roman, times;"><span style="font-size:small;"><span style="font-family:arial, helvetica, sans-serif;"><span style="font-size:small;"><span style="background: SpringGreen;">mp2_d1</span>&nbsp;</span></span></span></span></span></span></span></span></span></span>&nbsp;<span style="background: SpringGreen;">res</span> <span style="background: SpringGreen;">4</span>&nbsp;<span style="background: SpringGreen;">(</span><span style="background: SpringGreen;">GBMV)</span></p> </span></span></span></span></span></span></span></span></span></span></td> </tr> <tr style="mso-yfti-irow:5;"> <td width="319" valign="top" class="style15" style="width:239.4pt;"> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman, times;"><span style="font-size:small;"><span style="font-family:arial, helvetica, sans-serif;"><span style="font-size:small;">&nbsp; <a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/0143.ala5_5F00_4.pp.pmf.png"><span style="background: SpringGreen;"><img src="/cs/resized-image.ashx/__size/400x0/__key/CommunityServer.Wikis.Components.Files/computchem/0143.ala5_5F00_4.pp.pmf.png" border="0" alt="" /></span></a></span></span></span></span></span><a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/4846.ala5_5F00_4_5F00_new.png"><span style="font-size:x-small;"><span style="font-family:times new roman, times;"><span style="font-size:small;"><span style="font-family:arial, helvetica, sans-serif;"><span style="font-size:small;"></span></span></span></span></span></a><br /><br /><span class="style10"><span style="color:#000080;"><span style="font-size:x-small;"><span style="font-family:times new roman, times;"><span style="font-size:small;"><span style="font-family:arial, helvetica, sans-serif;"><span style="font-size:small;"><span style="background: SpringGreen;">AlphaR</span> <span style="background: SpringGreen;">region</span> <span style="background: SpringGreen;">is</span> <span style="background: SpringGreen;">as</span> <span style="background: SpringGreen;">stable</span> <span style="background: SpringGreen;">as</span> <span style="background: SpringGreen;">PPII</span> <span style="background: SpringGreen;">region</span><span style="background: SpringGreen;">.</span> <span style="background: SpringGreen;">Helicity</span> <span style="background: SpringGreen;">is</span> <span style="background: SpringGreen;">building</span> <span style="background: SpringGreen;">up</span> <span style="background: SpringGreen;">as</span> <span style="background: SpringGreen;">the</span> <span style="background: SpringGreen;">peptide</span> <span style="background: SpringGreen;">lengths</span> <span style="background: SpringGreen;">increases</span><span style="background: SpringGreen;">.</span> <span style="background: SpringGreen;">This</span> <span style="background: SpringGreen;">has</span> <span style="background: SpringGreen;">to</span> <span style="background: SpringGreen;">do</span> <span style="background: SpringGreen;">with</span> <span style="background: SpringGreen;">overstabilization</span> <span style="background: SpringGreen;">of</span> <span style="background: SpringGreen;">hydrogen</span> <span style="background: SpringGreen;">bonding</span> <span style="background: SpringGreen;">in</span> <span style="background: SpringGreen;">GB</span><span style="background: SpringGreen;">.</span></span></span></span></span></span></span></span></p> </td> <td width="319" valign="top" class="style15" style="width:239.4pt;"> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman, times;"><span style="font-size:small;"><span style="font-family:arial, helvetica, sans-serif;"><span style="font-size:small;">&nbsp; <a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/5852.ala5_5F00_gbmv_5F00_4.pmf.png"><span style="background: SpringGreen;"><img src="/cs/resized-image.ashx/__size/400x0/__key/CommunityServer.Wikis.Components.Files/computchem/5852.ala5_5F00_gbmv_5F00_4.pmf.png" border="0" alt="" /></span></a><a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/1104.ala5_5F00_4.pp.pmf.png"></a></span></span></span></span></span></p> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman, times;"><span style="font-size:small;"><span style="font-family:arial, helvetica, sans-serif;"><span style="font-size:small;"><span class="style10"><span style="color:#000080;"><span style="font-size:x-small;"><span style="font-family:times new roman, times;"><span style="font-size:small;"><span style="font-family:arial, helvetica, sans-serif;"><span style="font-size:small;"><span style="background: SpringGreen;">AlpahaR</span> <span style="background: SpringGreen;">region</span> <span style="background: SpringGreen;">is</span> <span style="background: SpringGreen;">less</span> <span style="background: SpringGreen;">stable</span> <span style="background: SpringGreen;">than</span> <span style="background: SpringGreen;">GBSW</span><span style="background: SpringGreen;">.</span>&nbsp;</span></span></span></span></span></span></span><a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/5187.ala5_5F00_4.pp.pmf.png"></a></span></span></span></span></span></p> <a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/7635.ala5_5F00_4_5F00_old.png"><span style="font-size:x-small;"><span style="font-family:times new roman, times;"><span style="font-size:small;"><span style="font-family:arial, helvetica, sans-serif;"><span style="font-size:small;"></span></span></span></span></span></a></td> </tr> <tr style="mso-yfti-irow:6;mso-yfti-lastrow:yes;"> <td width="319" valign="top" class="style2" style="width:239.4pt;"> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman, times;"><span style="font-size:small;"><span style="font-family:arial, helvetica, sans-serif;"><span style="font-size:small;">&nbsp;<span style="background: SpringGreen;">J-coup</span>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <span style="background: SpringGreen;">res</span> <span style="background: SpringGreen;">2</span>&nbsp;<span style="background: SpringGreen;">expt</span>&nbsp;&nbsp;&nbsp;<span style="background: SpringGreen;">res</span> <span style="background: SpringGreen;">3</span>&nbsp; <span style="background: SpringGreen;">expt</span>&nbsp;&nbsp;&nbsp;<span style="background: SpringGreen;">res</span> <span style="background: SpringGreen;">4</span>&nbsp; <span style="background: SpringGreen;">expt</span></span></span></span></span></span></p> <span class="style2"> <p class="MsoPlainText"><span style="color:#000000;"><span style="font-size:x-small;"><span style="font-family:times new roman, times;"><span style="font-size:small;"><span style="font-family:arial, helvetica, sans-serif;"><span style="font-size:small;"><span style="background: SpringGreen;">3JHNHa</span>&nbsp;&nbsp; <span style="background: SpringGreen;">4.97</span>&nbsp;&nbsp;&nbsp;<span style="background: SpringGreen;">5.59</span>&nbsp;&nbsp;<span style="background: SpringGreen;">4.98</span>&nbsp;&nbsp;&nbsp;<span style="background: SpringGreen;">5.74</span>&nbsp; <span style="background: SpringGreen;">5.13</span>&nbsp;&nbsp;&nbsp; <span style="background: SpringGreen;">5.98</span><br /></span></span></span></span></span></span></p> </span></td> <td width="319" valign="top" class="style2" style="width:239.4pt;"> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman, times;"><span style="font-size:small;"><span style="font-family:arial, helvetica, sans-serif;"><span style="font-size:small;">&nbsp;<span style="background: SpringGreen;">J-coup</span>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <span style="background: SpringGreen;">res</span> <span style="background: SpringGreen;">2</span>&nbsp;&nbsp;<span style="background: SpringGreen;">expt</span>&nbsp; <span style="background: SpringGreen;">res</span> <span style="background: SpringGreen;">3</span>&nbsp;&nbsp;<span style="background: SpringGreen;">expt</span>&nbsp; <span style="background: SpringGreen;">res</span> <span style="background: SpringGreen;">4</span> <span style="background: SpringGreen;">expt</span></span></span></span></span></span></p> <p class="MsoNormal"><span style="font-family:Calibri;font-size:small;"><span class="style1"><span class="style5"><span class="style2"><span style="font-family:Arial;color:#000080;"><span style="font-size:x-small;"><span style="font-family:times new roman, times;"><span style="font-size:small;"><span style="font-family:arial, helvetica, sans-serif;"><span style="font-size:small;"><span style="color:#000000;"><span style="color:#000000;"><span style="font-size:x-small;"><span style="font-family:times new roman, times;"><span style="font-size:small;"><span style="font-family:arial, helvetica, sans-serif;"><span style="font-size:small;"><span style="background: SpringGreen;">3JHNHa</span>&nbsp;&nbsp;&nbsp; <span style="background: SpringGreen;">5.27</span>&nbsp;&nbsp;&nbsp;<span style="background: SpringGreen;">5.59</span>&nbsp; <span style="background: SpringGreen;">5.24</span>&nbsp;&nbsp;&nbsp;<span style="background: SpringGreen;">5.74</span>&nbsp;&nbsp;<span style="background: SpringGreen;">5.37</span> <span style="background: SpringGreen;">5.98</span> </span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></p> <p class="MsoNormal"><span style="font-family:Calibri;font-size:small;"><span class="style1"><span class="style5"><span class="style2"><span style="font-family:Arial;color:#000080;"><span style="font-size:x-small;"><span style="font-family:times new roman, times;"><span style="font-size:small;"><span style="font-family:arial, helvetica, sans-serif;"><span style="font-size:small;"><span style="color:#000000;"><span style="color:#000000;"><span style="font-size:x-small;"><span style="font-family:times new roman, times;"><span style="font-size:small;"><span style="font-family:arial, helvetica, sans-serif;"><span style="font-size:small;"></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span><span style="font-family:Calibri;font-size:small;"><span class="style1"><span class="style5"><span class="style2"><span style="font-family:Arial;color:#000080;"><span style="font-size:x-small;"><span style="font-family:times new roman, times;"><span style="font-size:small;"><span style="font-family:arial, helvetica, sans-serif;"><span style="font-size:small;"><span style="color:#000000;"><span style="color:#000000;"><span style="font-size:x-small;"><span style="font-family:times new roman, times;"><span style="font-size:small;"><span style="font-family:arial, helvetica, sans-serif;"><span style="font-size:small;"><span style="background: SpringGreen;">GBMV</span> <span style="background: SpringGreen;">gives</span> <span style="background: SpringGreen;">better</span> <span style="background: SpringGreen;">agreement</span> <span style="background: SpringGreen;">with</span> <span style="background: SpringGreen;">expt</span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></p> </td> </tr> </tbody> </table> <table cellpadding="0" cellspacing="0" border="1" class="style16" style="mso-border-alt:solid black .5pt;mso-border-themecolor:text1;mso-yfti-tbllook:1184;mso-padding-alt:0pt 5.4pt 0pt 5.4pt;"> <tbody> <tr style="mso-yfti-irow:0;mso-yfti-firstrow:yes;"> <td width="319" valign="top" class="style13" style="width:239.4pt;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"> <p class="MsoNormal"><span style="background: SpringGreen;">mp2_d2</span>&nbsp;&nbsp;<span style="background: SpringGreen;">res</span> <span style="background: SpringGreen;">2</span> </p> </span></span></span></span></td> <td width="319" valign="top" class="style14" style="width:239.4pt;"> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;">&nbsp;<span style="background: SpringGreen;">mp2_d2</span> <span style="background: SpringGreen;">res</span> <span style="background: SpringGreen;">2</span> <span style="background: SpringGreen;">(</span><span style="background: SpringGreen;">GBMV)</span></span></span></span></span></p> </td> </tr> <tr style="mso-yfti-irow:1;"> <td width="319" valign="top" class="style15" style="width:239.4pt;"> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;">&nbsp;<a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/2022.ala5_5F00_2.pmf.png"><span style="background: SpringGreen;"><img src="/cs/resized-image.ashx/__size/400x0/__key/CommunityServer.Wikis.Components.Files/computchem/2022.ala5_5F00_2.pmf.png" border="0" alt="" /></span></a> <a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/8473.ala5_5F00_2.pp.pmf.png"></a></span></span></span></span></p> </td> <td width="319" valign="top" class="style15" style="width:239.4pt;"> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;">&nbsp; <a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/6683.ala5_5F00_gbmv_5F00_2.pmf.png"></a><a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/6064.ala5_5F00_2.pp.pmf.png"></a></span></span></span></span></p> <p class="MsoNormal"><span class="style10"><span style="color:#000080;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"></span></span></span></span></span></span></p> </td> </tr> <tr style="mso-yfti-irow:2;"> <td width="319" valign="top" class="style2" style="width:239.4pt;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"> <p class="MsoNormal"><span style="background: SpringGreen;">mp2_d2</span> &nbsp;<span style="background: SpringGreen;">res</span> <span style="background: SpringGreen;">3</span> </p> </span></span></span></span></td> <td width="319" valign="top" class="style2" style="width:239.4pt;"> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="background: SpringGreen;">mp2_d2</span>&nbsp;<span style="background: SpringGreen;">res</span> <span style="background: SpringGreen;">3</span> <span style="background: SpringGreen;">(</span><span style="background: SpringGreen;">GBMV)</span></span></span></span></span></p> </td> </tr> <tr style="mso-yfti-irow:3;"> <td width="319" valign="top" class="style2" style="width:239.4pt;"> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/3286.ala5_5F00_3.pmf.png"><span style="background: SpringGreen;"><img src="/cs/resized-image.ashx/__size/400x0/__key/CommunityServer.Wikis.Components.Files/computchem/3286.ala5_5F00_3.pmf.png" border="0" alt="" /></span></a>&nbsp; </span></span></span></span></p> </td> <td width="319" valign="top" class="style2" style="width:239.4pt;"> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;">&nbsp; <a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/1263.ala5_5F00_gbmv_5F00_3.pmf.png"></a><a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/1488.ala5_5F00_3.pp.pmf.png"></a></span></span></span></span></p> <p class="MsoNormal"><span class="style10"><span style="color:#000080;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"></span></span></span></span></span></span></p> </td> </tr> <tr style="mso-yfti-irow:4;"> <td width="319" valign="top" class="style14" style="width:239.4pt;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"> <p class="MsoNormal"><span style="background: SpringGreen;">mp2_d2</span>&nbsp;&nbsp;<span style="background: SpringGreen;">res</span> <span style="background: SpringGreen;">4</span> </p> </span></span></span></span></td> <td width="319" valign="top" class="style14" style="width:239.4pt;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"> <p class="MsoNormal"><span style="background: SpringGreen;">mp2_d2</span>&nbsp;&nbsp;<span style="background: SpringGreen;">res</span> <span style="background: SpringGreen;">4</span>&nbsp;<span style="background: SpringGreen;">(</span><span style="background: SpringGreen;">GBMV)</span></p> </span></span></span></span></td> </tr> <tr style="mso-yfti-irow:5;"> <td width="319" valign="top" class="style15" style="width:239.4pt;"> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;">&nbsp;<a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/7026.ala5_5F00_4.pmf.png"><span style="background: SpringGreen;"><img src="/cs/resized-image.ashx/__size/400x0/__key/CommunityServer.Wikis.Components.Files/computchem/7026.ala5_5F00_4.pmf.png" border="0" alt="" /></span></a> </span></span></span></span><br /><span class="style10"><span style="color:#000080;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="background: SpringGreen;">AlphaR</span> <span style="background: SpringGreen;">region</span> <span style="background: SpringGreen;">is</span> <span style="background: SpringGreen;">as</span> <span style="background: SpringGreen;">stable</span> <span style="background: SpringGreen;">as</span> <span style="background: SpringGreen;">PPII</span> <span style="background: SpringGreen;">region</span><span style="background: SpringGreen;">.</span> <span style="background: SpringGreen;">Helicity</span> <span style="background: SpringGreen;">is</span> <span style="background: SpringGreen;">building</span> <span style="background: SpringGreen;">up</span> <span style="background: SpringGreen;">as</span> <span style="background: SpringGreen;">the</span> <span style="background: SpringGreen;">peptide</span> <span style="background: SpringGreen;">lengths</span> <span style="background: SpringGreen;">increases</span><span style="background: SpringGreen;">.</span> <span style="background: SpringGreen;">This</span> <span style="background: SpringGreen;">has</span> <span style="background: SpringGreen;">to</span> <span style="background: SpringGreen;">do</span> <span style="background: SpringGreen;">with</span> <span style="background: SpringGreen;">overstabilization</span> <span style="background: SpringGreen;">of</span> <span style="background: SpringGreen;">hydrogen</span> <span style="background: SpringGreen;">bonding</span> <span style="background: SpringGreen;">in</span> <span style="background: SpringGreen;">GB</span><span style="background: SpringGreen;">.</span></span></span></span></span></span></span></p> </td> <td width="319" valign="top" class="style15" style="width:239.4pt;"> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;">&nbsp; <a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/5852.ala5_5F00_gbmv_5F00_4.pmf.png"></a><a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/1104.ala5_5F00_4.pp.pmf.png"></a></span></span></span></span></p> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span class="style10"><span style="color:#000080;">&nbsp;</span></span><a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/5187.ala5_5F00_4.pp.pmf.png"></a></span></span></span></span></p> </td> </tr> <tr style="mso-yfti-irow:6;mso-yfti-lastrow:yes;"> <td width="319" valign="top" class="style2" style="width:239.4pt;"> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;">&nbsp;<span style="background: SpringGreen;">J-coup</span>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <span style="background: SpringGreen;">res</span> <span style="background: SpringGreen;">2</span>&nbsp;<span style="background: SpringGreen;">expt</span>&nbsp;&nbsp;&nbsp;<span style="background: SpringGreen;">res</span> <span style="background: SpringGreen;">3</span>&nbsp; <span style="background: SpringGreen;">expt</span>&nbsp;&nbsp;&nbsp;<span style="background: SpringGreen;">res</span> <span style="background: SpringGreen;">4</span>&nbsp; <span style="background: SpringGreen;">expt</span></span></span></span></span></p> <span class="style2"> <p class="MsoPlainText"><span style="color:#000000;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="background: SpringGreen;">3JHNHa</span>&nbsp;&nbsp; <span style="background: SpringGreen;">5.05</span>&nbsp;&nbsp;&nbsp;<span style="background: SpringGreen;">5.59</span>&nbsp;&nbsp;<span style="background: SpringGreen;">5.25</span>&nbsp;&nbsp;&nbsp;<span style="background: SpringGreen;">5.74</span>&nbsp; <span style="background: SpringGreen;">5.33</span>&nbsp;&nbsp;&nbsp; 5.98<br /></span></span></span></span></span></p> </span></td> <td width="319" valign="top" class="style2" style="width:239.4pt;"> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;">&nbsp;J-coup&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; res 2&nbsp;&nbsp;expt&nbsp; res 3&nbsp;&nbsp;expt&nbsp; res 4 expt</span></span></span></span></p> <p class="MsoNormal"><span style="font-family:Calibri;font-size:small;"><span class="style1"><span class="style5"><span class="style2"><span style="font-family:Arial;color:#000080;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="color:#000000;">3JHNHa&nbsp;&nbsp;&nbsp; 5.27&nbsp;&nbsp;&nbsp;5.59&nbsp; 5.24&nbsp;&nbsp;&nbsp;5.74&nbsp;&nbsp;5.37 5.98 </span></span></span></span></span></span></span></span></span></span></p> <p class="MsoNormal"><span style="font-family:Calibri;font-size:small;"><span class="style1"><span class="style5"><span class="style2"><span style="font-family:Arial;color:#000080;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="color:#000000;">GBMV gives better agreement with expt</span></span></span></span></span></span></span></span></span></span></p> </td> </tr> </tbody> </table> </span></span></span></span></span></h4> <p> <h4><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">(AAQAA)3</span></span></span></span></span></h4> <p><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">30 ns REX-GBSW simulations, data collected in the last 5 ns&nbsp;at&nbsp;275 (red) and 300 K (green). Convergence verified by evaluating 30-40 ns data and compare it with 25-30 ns.</span></span></span></span></span></p> <p> <table cellpadding="0" cellspacing="0" border="1" class="style16" style="mso-border-alt:solid black .5pt;mso-border-themecolor:text1;mso-yfti-tbllook:1184;mso-padding-alt:0pt 5.4pt 0pt 5.4pt;"> <tbody> <tr style="mso-yfti-irow:0;mso-yfti-firstrow:yes;"> <td width="319" valign="top" class="style13" style="width:239.4pt;"> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">New CMAP (helicity based on hydrogen bonding)</span></span></span></span></span></p> </td> <td width="319" valign="top" class="style14" style="width:239.4pt;"> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">Old CMAP (helicity based on hydrogen bonding)</span></span></span></span></span></p> </td> </tr> <tr style="mso-yfti-irow:1;mso-yfti-lastrow:yes;"> <td width="319" valign="top" class="style15" style="width:239.4pt;"> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">&nbsp;<span class="style1"><a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/4810.aaqaa.helix2res.png"></a><a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/8473.aaqaa.hbond_2D00_helix2res.png"></a><a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/7840.aaqaa.hbond_2D00_helix2res.png"></a></span> </span></span></span></span></span><a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/8787.aaqaa_5F00_new.png"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><img src="/cs/resized-image.ashx/__size/400x0/__key/CommunityServer.Wikis.Components.Files/computchem/8787.aaqaa_5F00_new.png" border="0" alt="" /></span></span></span></span></span></a><br /><br /><span class="style10"><span style="color:#000080;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">Residue-averaged helix content is comparable to experiment although helicity for residues in the middle is significantly higher. We will investigate the backbone hydrogen bonding.</span></span></span></span></span></span></span></p> </td> <td width="319" valign="top" class="style15" style="width:239.4pt;"> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">&nbsp;<span class="style1"><a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/8053.aaqaa.helix2res.png"></a><a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/3652.aaqaa.helix2res.png"></a></span>&nbsp;</span></span></span></span></span><a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/4130.aaqaa_5F00_old.png"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><img src="/cs/resized-image.ashx/__size/400x0/__key/CommunityServer.Wikis.Components.Files/computchem/4130.aaqaa_5F00_old.png" border="0" alt="" /></span></span></span></span></span></a><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"> </span></span></span></span></span></p> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">GBSW CMAP</span></span></span></span></span></p> <p class="MsoNormal"><a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/3527.aaqaa.old_2D00_cmap.png"></a><a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/0160.aaqaa_5F00_gbsw.png"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><img src="/cs/resized-image.ashx/__size/400x0/__key/CommunityServer.Wikis.Components.Files/computchem/0160.aaqaa_5F00_gbsw.png" border="0" alt="" /></span></span></span></span></span></a><br /><br /><span class="style10"><span style="color:#000080;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">Good agreement because the backbone atomic radii were optimized to match the experimental data.</span></span></span></span></span></span></span></p> </td> </tr> </tbody> </table> </p> <p class="style3"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">&nbsp;</span></span></span></span></span></p> <h4 class="style3"><a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/1200.aaqaa.hbond_2D00_helix2res.png"></a><span class="style7"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">HP36 fragments (test influence from side chains): </span></span></span></span></span></span></h4> <p class="style3"><span class="style4"><span style="color:#000080;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">helicity assigned by DSSP</span></span></span></span></span></span></span></p> <p class="style3"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">HP13 (N-terminal 13 residues)<br /><br /></span></span></span></span></span></p> <p class="style3"><a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/5460.hp13.helix2res_2D00_all.png"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><img src="/cs/resized-image.ashx/__size/800x0/__key/CommunityServer.Wikis.Components.Files/computchem/5460.hp13.helix2res_2D00_all.png" border="0" alt="" /></span></span></span></span></span></a></p> <p class="style5"><span style="color:#000080;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">With the new CMAP, overall helicity is significantly reduced. NMR J coupling data suggests sparsely populated helical states. We will compare with J coupling data.</span></span></span></span></span></span></p> <p class="style3"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span class="style19">C-terminal 14 residues</span><br /><br /></span></span></span></span></span><a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/6470.ct14_2D00_all.helix.png"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><img src="/cs/resized-image.ashx/__size/800x0/__key/CommunityServer.Wikis.Components.Files/computchem/6470.ct14_2D00_all.helix.png" border="0" alt="" /></span></span></span></span></span></a></p> <p class="style5"><span style="color:#000080;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">New CMAP (red) gave much lower helicity in agreement with experiment. We need to compare with NMR data which suggests low helicity.</span></span></span></span></span></span></p> <p class="style3"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">Middle 10 residues<br /><br /></span></span></span></span></span></p> <p class="style3"><a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/4721.mid10_2D00_all.helix.png"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><img src="/cs/resized-image.ashx/__size/800x0/__key/CommunityServer.Wikis.Components.Files/computchem/4721.mid10_2D00_all.helix.png" border="0" alt="" /></span></span></span></span></span></a></p> <p class="style3"><span class="style4"><span style="color:#000080;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">This is an exception: new CMAP (red) gives slightly higher helicity for residues in the middle of the sequence. NMR data suggests no helicity.</span></span></span></span></span></span></span></p> </p>http://computchem.org/cs/wikis/computchem/cmap-testing/revision/54.aspxFri, 19 Feb 2010 15:18:11 GMT1b863b40-6314-48da-8368-fb96d4c4a8e3:58JanaRevision 54 posted to Computational Chemistry and Biophysics Wiki by Jana on 2/19/2010 9:18:11 AM<br /> <h2>CMAP testing</h2> <p><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;">&nbsp; </span></span></span></span></p> <h4 class="style8"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">Test the performance of new CHARMM torsion potential for GBSW implicit-solvent simulations</span></span></span></span></span></h4> <p><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span class="style1"><span class="style2">New CMAP (par_mod24_2_6.prm): recently optimized by the Feig group at MSU&nbsp;to correct for the helical bias vs extended regions<br /><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"></span></span></span></span></span></span></span></span></span></span></span></span></p> <p><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span class="style1"><span class="style2"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">par31_2_6: same CMAP as above but with the new force field for alkanes from the MacKerell group at UMBT</span></span></span></span></span></span></span></span></span></span></span></span></p> <p><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span class="style1"><span class="style2"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"></span></span></span></span></span></span> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">par31feigmp2_d1: CMAP optimized based on the<span style="text-decoration: line-through; color: red;">quantum</span> &nbsp;<span style="background: SpringGreen;">MP2</span> map <span style="background: SpringGreen;">version</span> <span style="background: SpringGreen;">1</span></span></span></span></span></span></span></span></span></span></span></p> </span>GBSW CMAP (par_all22_prot_gbsw.inp): an analytic function was added to the old CMAP to correct for the helical bias for GBSW implicit-solvent simulations. GBSW CMAP was able to fold both helical and beta-sheet proteins (Chen et al,&nbsp;JACS 2006)</span></span></span></span></span></p> <p>&nbsp;<span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="background: SpringGreen;">par31feigmp2_d2</span><span style="background: SpringGreen;">:</span> <span style="background: SpringGreen;">CMAP</span> <span style="background: SpringGreen;">optimized</span> <span style="background: SpringGreen;">based</span> <span style="background: SpringGreen;">on</span> <span style="background: SpringGreen;">the</span> <span style="background: SpringGreen;">MP2</span> <span style="background: SpringGreen;">map</span> <span style="background: SpringGreen;">version</span> <span style="background: SpringGreen;">2</span></span></span></span></span></span></span></span></span></span></span></p> <p>&nbsp;</p> <p>Old CMAP (par_all22_prot_cmap.inp): Phi, Psi grid map to correction for overstabilization of pi helix <br />(Feig et al, JPCB 2003, MacKerell et al, JCC 2004, MacKerell et al, JACS 2004)</p> <h4 class="style7"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">Ala dipeptide</span></span></span></span></span></h4> <p><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">20 ns REX-GBSW simulations, data collected in the last 5 ns at 298 K</span></span></span></span></span></p> <p> <table cellpadding="0" cellspacing="0" border="1" class="style16" style="mso-border-alt:solid black .5pt;mso-border-themecolor:text1;mso-yfti-tbllook:1184;mso-padding-alt:0pt 5.4pt 0pt 5.4pt;"> <tbody> <tr style="mso-yfti-irow:0;mso-yfti-firstrow:yes;"> <td width="319" valign="top" class="style13" style="width:239.4pt;"> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="text-decoration: line-through; color: red;">par31feigmp2_d1</span></span></span></span></span></span></span></span></span></span></span></p> </td> <td valign="top" class="style14" style="width:251pt;"> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="text-decoration: line-through; color: red;">par31_2_6</span></span></span></span></span></span></p> <p> <table cellpadding="0" cellspacing="0" border="1" class="style16" style="mso-border-alt:solid black .5pt;mso-border-themecolor:text1;mso-yfti-tbllook:1184;mso-padding-alt:0pt 5.4pt 0pt 5.4pt;"> <tbody> <tr style="mso-yfti-irow:0;mso-yfti-firstrow:yes;"> <td width="319" valign="top" class="style13" style="width:239.4pt;"> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="background: SpringGreen;">mp2_d1</span></span></span></span></span></span></span></span></span></span></span></p> </td> <td valign="top" class="style14" style="width:251pt;"> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="background: SpringGreen;">mp2_d2</span></span></span></span></span></span></span></span></span></span></span></p> </td> </tr> <tr style="mso-yfti-irow:1;"> <td width="319" valign="top" class="style15" style="width:239.4pt;"><a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/4274.ala_5F00_new.png"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"></span></span></span></span></span></a> <p class="MsoNormal"><a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/4118.ala.pmf.png"><img src="/cs/resized-image.ashx/__size/400x0/__key/CommunityServer.Wikis.Components.Files/computchem/4118.ala.pmf.png" border="0" alt="" /></a><br /><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span class="style10"><span style="color:#000080;">Comparison to explicit-solvent results: <span style="text-decoration: line-through; color: red;">Diff(AlphaR</span><span style="text-decoration: line-through; color: red;">,</span> <span style="text-decoration: line-through; color: red;">PPII</span><span style="text-decoration: line-through; color: red;">)</span> <span style="text-decoration: line-through; color: red;">is</span>&nbsp;<span style="text-decoration: line-through; color: red;">too</span> <span style="text-decoration: line-through; color: red;">small</span> <span style="text-decoration: line-through; color: red;">by</span> <span style="text-decoration: line-through; color: red;">1</span> <span style="text-decoration: line-through; color: red;">kcal/mol</span><span style="text-decoration: line-through; color: red;">.</span> PPII is not enough deep or AlpaR is not enough high.</span></span></span></span></span></span></span></p> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span class="style10"><span style="color:#000080;"><span style="color:#000000;">GBMV</span></span></span></span></span></span></span></span></p> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span class="style10"><span style="color:#000080;"><a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/0841.ala_5F00_gbmv.pmf.png"><img src="/cs/resized-image.ashx/__size/400x0/__key/CommunityServer.Wikis.Components.Files/computchem/0841.ala_5F00_gbmv.pmf.png" border="0" alt="" /></a></span></span></span></span></span></span></span></p> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span class="style10"><span style="color:#000080;"><span style="text-decoration: line-through; color: red;">Compare</span> <span style="text-decoration: line-through; color: red;">to</span> <span style="text-decoration: line-through; color: red;">GBSW</span><span style="text-decoration: line-through; color: red;">:</span> <span style="text-decoration: line-through; color: red;">alpha-L</span> <span style="text-decoration: line-through; color: red;">region</span> <span style="text-decoration: line-through; color: red;">more</span> <span style="text-decoration: line-through; color: red;">stable</span></a></span></span></span></span></span></span></span></p> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span class="style10"><span style="color:#000080;"><span style="background: SpringGreen;">Similar</span></span></span></span></span></span></span></span></p> </td> <td valign="top" class="style15" style="width:251pt;"><a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/2845.ala_5F00_old.png"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"></span></span></span></span></span></a> <p class="MsoNormal"><a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/2146.ala.pmf.png"></a><a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/3146.ala.pmf.png"><img src="/cs/resized-image.ashx/__size/400x0/__key/CommunityServer.Wikis.Components.Files/computchem/3146.ala.pmf.png" border="0" alt="" /></a><br /><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span class="style10"><span style="color:#000080;"></span></span></span></span></span></span></span></p> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="color:#000080;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span class="style10"><span style="color:#000080;"><span style="text-decoration: line-through; color: red;">More</span> </a><br /><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span class="style10"><span style="color:#000080;"></span></span></span></span></span></span></span></p> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="color:#000080;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span class="style10"><span style="color:#000080;"><span style="background: SpringGreen;">Even</span> <span style="background: SpringGreen;">more</span> helical</span></span></span></span></span></span></span></span></span></span></span></span></span></p> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="color:#000080;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="color:#000080;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span class="style10"><span style="color:#000080;"><span style="color:#000000;">GBMV<span style="text-decoration: line-through; color: red;">(</span><span style="text-decoration: line-through; color: red;">stilll</span> <span style="text-decoration: line-through; color: red;">to</span> <span style="text-decoration: line-through; color: red;">come...</span><span style="text-decoration: line-through; color: red;">)</span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></p> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="color:#000080;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="color:#000080;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span class="style10"><span style="color:#000080;"><span style="color:#000000;"></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/6763.ala_5F00_gbmv.pmf.png"></a><br />&nbsp;</span></span></span></span></span></span></span></span></span></span></p> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"></span></span></span></span></span><span class="style10"><span style="color:#000080;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span class="style10"><span style="color:#000080;"><span style="text-decoration: line-through; color: red;">Very</span> <span style="text-decoration: line-through; color: red;">similar</span> <span style="text-decoration: line-through; color: red;">to</span> <span style="text-decoration: line-through; color: red;">the</span> <span style="text-decoration: line-through; color: red;">GBSW</span> <span style="text-decoration: line-through; color: red;">map</span><span style="text-decoration: line-through; color: red;">.</span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></p> </td> </tr> <tr style="mso-yfti-irow:2;mso-yfti-lastrow:yes;"> <td width="319" valign="top" class="style2" style="width:239.4pt;"> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">&nbsp;<span style="text-decoration: line-through; color: red;">J-coupling</span> <span style="text-decoration: line-through; color: red;">data</span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></p> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="color:#000080;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="color:#000080;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span class="style10"><span style="color:#000080;"><span style="color:#000000;"></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/6763.ala_5F00_gbmv.pmf.png"></a><a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/8561.ala_5F00_gbmv.pmf.png"><span style="background: SpringGreen;"><img src="/cs/resized-image.ashx/__size/400x0/__key/CommunityServer.Wikis.Components.Files/computchem/8561.ala_5F00_gbmv.pmf.png" border="0" alt="" /></span></a><br />&nbsp;</span></span></span></span></span></span></span></span></span></span><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span class="style10"><span style="color:#000080;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span class="style10"><span style="color:#000080;"><span style="background: SpringGreen;">Less</span> <span style="background: SpringGreen;">helical</span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></span></p> </td> </tr> <tr style="mso-yfti-irow:2;mso-yfti-lastrow:yes;"> <td width="319" valign="top" class="style2" style="width:239.4pt;"> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">&nbsp;</span></span></span></span></span><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"></span></span></span></span></span><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; expt&nbsp;&nbsp;&nbsp; GBSW&nbsp;&nbsp;&nbsp; GBMV</span></span></span></span></span></p> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"></span></span></span></span></span><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">3JHNHa:&nbsp;5.68&nbsp;&nbsp;&nbsp; </span></span></span></span></span></p> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="text-decoration: line-through; color: red;">time</span> <span style="text-decoration: line-through; color: red;">average</span>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; 5.09&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <span style="text-decoration: line-through; color: red;">5.66</span></span></span></span></span></span><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </span></span></span></span></span></p> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="text-decoration: line-through; color: red;">from</span>&nbsp;<span style="text-decoration: line-through; color: red;">PMF</span>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp;<span style="text-decoration: line-through; color: red;">3.95</span>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <span style="text-decoration: line-through; color: red;">4.39</span></span></span></span></span></span><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><br /><span style="text-decoration: line-through; color: red;">chi-square</span>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <span style="text-decoration: line-through; color: red;">5.04</span>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <span style="text-decoration: line-through; color: red;">4.98</span></span></span></span></span></span></p> </td> <td valign="top" class="style2" style="width:251pt;"> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">&nbsp;<span style="text-decoration: line-through; color: red;">J-coupling</span> <span style="text-decoration: line-through; color: red;">data</span>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <span style="background: SpringGreen;">5.67</span></span></span></span></span></span><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </span></span></span></span></span></p> </td> <td valign="top" class="style2" style="width:251pt;"> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; expt&nbsp;&nbsp;&nbsp; GBSW&nbsp;&nbsp;&nbsp; GBMV</span></span></span></span></span></p> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"></span></span></span></span></span><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">3JHNHa:&nbsp;5.68&nbsp;&nbsp;&nbsp; </span></span></span></p> <p class="MsoNormal"><span class="style1"><span class="style5" style="line-height:115%;mso-ascii-theme-font:minor-latin;mso-fareast-font-family:SimSun;mso-fareast-theme-font:minor-fareast;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:&#39;Times New Roman&#39;;mso-bidi-theme-font:minor-bidi;mso-ansi-language:EN-US;mso-fareast-language:ZH-CN;mso-bidi-language:AR-SA;"><span style="font-size:small;"><span style="text-decoration: line-through; color: red;">time</span> <span style="text-decoration: line-through; color: red;">average</span>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <span style="text-decoration: line-through; color: red;">5.09</span>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <span style="text-decoration: line-through; color: red;">5.61</span></span></span></span></p> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="text-decoration: line-through; color: red;">from</span>&nbsp;<span style="text-decoration: line-through; color: red;">PMF</span>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp; <span style="text-decoration: line-through; color: red;">3.26</span>&nbsp;&nbsp;&nbsp;&nbsp; &nbsp;&nbsp;<span style="text-decoration: line-through; color: red;">3.76</span></span></span></span></span></span><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><br /><span style="text-decoration: line-through; color: red;">chi-square</span>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp; &nbsp;<span style="text-decoration: line-through; color: red;">9.20</span>&nbsp;&nbsp; &nbsp;&nbsp;&nbsp; <span style="text-decoration: line-through; color: red;">7.48</span>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <span style="background: SpringGreen;">5.20</span>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; <span style="background: SpringGreen;">5.64</span></span></span></span></span></span><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span></span></span></span></span></p> </td> </tr> </tbody> </table> </p> <h4><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span class="style7">Ala3 (free N-ter and protonated C-ter)</span>&nbsp;</span></span></span></span></span></h4> <p><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">20 ns REX-GBSW simulations, data collected in the last 5 ns at 298 K. </span></span></span></span></span><a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/7444.ala3_5F00_2.pp.pmf.png"><br /></a></p> <p> <table cellpadding="0" cellspacing="0" border="1" class="style16" style="mso-border-alt:solid black .5pt;mso-border-themecolor:text1;mso-yfti-tbllook:1184;mso-padding-alt:0pt 5.4pt 0pt 5.4pt;"> <tbody> <tr style="mso-yfti-irow:0;mso-yfti-firstrow:yes;"> <td width="319" valign="top" class="style13" style="width:239.4pt;"> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">&nbsp;<span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">par31feigmp2_d1 </span></span></span></span></span></span></span></span></span></span>residue #2</span></span></span></span></span></p> </td> <td width="319" valign="top" class="style14" style="width:239.4pt;"> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">par31_2_6&nbsp;residue #2</span></span></span></span></span></p> </td> </tr> <tr style="mso-yfti-irow:1;"> <td width="319" valign="top" class="style15" style="width:239.4pt;"> <p class="MsoNormal"><span style="font-family:Calibri;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">&nbsp;<a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/7230.ala3_5F00_2.pmf.png"><img src="/cs/resized-image.ashx/__size/400x0/__key/CommunityServer.Wikis.Components.Files/computchem/7230.ala3_5F00_2.pmf.png" border="0" alt="" /></a></span></span></span></span></span></span><a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/0317.ala3_5F00_2_5F00_new.png"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"></span></span></span></span></span></a><br /><span class="style10"><span style="color:#000080;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">AlphaR is too stable.</span></span></span></span></span></span></span></p> </td> <td width="319" valign="top" class="style15" style="width:239.4pt;"> <p class="MsoNormal"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">&nbsp; <a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/7343.ala3_5F00_2.pp.pmf.png"><img src="/cs/resized-image.ashx/__size/400x0/__key/CommunityServer.Wikis.Components.Files/computchem/7343.ala3_5F00_2.pp.pmf.png" border="0" alt="" /></a></span></span></span></span></span><a href="/cs/cfs-file.ashx/__key/CommunityServer.Wikis.Components.Files/computchem/4527.ala3_5F00_2_5F00_old.png"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"></span></span></span></span></span></a><br /><span class="style10"><span style="color:#000080;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">Similar to Ala dipep map.&nbsp;Alpha-L is too high&nbsp;as compared to explicit-solvent data&nbsp;(consistent with the ala-dipep map).</span></span></span></span></span></span></span></p> </td> </tr> <tr style="mso-yfti-irow:2;mso-yfti-lastrow:yes;"> <td width="319" valign="top" class="style2" style="width:239.4pt;"> <p class="MsoNormal"><span style="color:#000000;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span class="style1"><span class="style5"><span class="style2">Time averaged NMR coupling <br />&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; simulation&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; expt</span></span></span> </span></span></span></span></span></span></p> <p class="MsoNormal"><span style="font-family:Arial;"><span style="color:#000000;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span class="style1"><span class="style5" style="line-height:115%;mso-ascii-theme-font:minor-latin;mso-fareast-font-family:SimSun;mso-fareast-theme-font:minor-fareast;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:&#39;Times New Roman&#39;;mso-bidi-theme-font:minor-bidi;mso-ansi-language:EN-US;mso-fareast-language:ZH-CN;mso-bidi-language:AR-SA;"><span class="style2">3JHNHa&nbsp; 4.93&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; 5.68<br />3JHNCp&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; 1.13<br />3JHACp&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; 1.84<br />3JCpCp&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp; 0.25<br />3JHNCb&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp;2.39<br />1JNCa&nbsp;&nbsp;&nbsp;&nbsp;11.04&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; 11.34<br />2JNCa&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; 7.92&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; 8.45</span></span></span> <br /><br /><span class="style10">Much better agreement with experiment!</span></span></span></span></span></span></span></span></p> </td> <td width="319" valign="top" class="style2" style="width:239.4pt;"> <p class="MsoNormal"><span class="style1" style="font-family:Calibri;font-size:small;"><span class="style5"><span class="style2"><span style="font-size:x-small;"><span style="color:#000000;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">Time averaged NMR coupling <br />&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; simulation&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</span></span></span></span></span></span></span></span></span></span></p> <p class="MsoNormal"><span class="style1" style="font-family:Calibri;font-size:small;"><span class="style5"><span class="style2"><span style="font-size:x-small;"><span style="color:#000000;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span style="font-family:Arial;"><span style="color:#000000;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"><span class="style1"><span class="style5" style="line-height:115%;mso-ascii-theme-font:minor-latin;mso-fareast-font-family:SimSun;mso-fareast-theme-font:minor-fareast;mso-hansi-theme-font:minor-latin;mso-bidi-font-family:&#39;Times New Roman&#39;;mso-bidi-theme-font:minor-bidi;mso-ansi-language:EN-US;mso-fareast-language:ZH-CN;mso-bidi-language:AR-SA;"><span class="style2">3JHNHa&nbsp;&nbsp; &nbsp;5.00</span></span></span></span></span></span></span></span></span></span>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </span></span></span></span></span></span></span></span></span></span></p> <p class="MsoNormal"><span class="style1" style="font-family:Calibri;font-size:small;"><span class="style5"><span class="style2"><span style="font-size:x-small;"><span style="color:#000000;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"></span></span></span></span></span></span></span></span></span></span><span class="style1" style="font-family:Calibri;font-size:small;"><span class="style5"><span class="style2"><span style="font-size:x-small;"><span style="color:#000000;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">1JNCa&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp;</span></span></span></span></span></span></span></span></span></span><span class="style1" style="font-family:Calibri;font-size:small;"><span class="style5"><span class="style2"><span style="font-size:x-small;"><span style="color:#000000;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">1.19&nbsp;&nbsp; </span></span></span></span></span></span></span></span></span></span></p> <p class="MsoNormal"><span class="style1" style="font-family:Calibri;font-size:small;"><span class="style5"><span class="style2"><span style="font-size:x-small;"><span style="color:#000000;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;"></span></span></span></span></span></span></span></span></span></span><span class="style1" style="font-family:Calibri;font-size:small;"><span class="style5"><span class="style2"><span style="font-size:x-small;"><span style="color:#000000;"><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">2JNCa&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; 8.18<br />&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </span></span></span></span></span></span></span></span></span></span></p> </td> </tr> </tbody> </table> </p> <p> <p><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">&nbsp;</span></span></span></span></span></p> <h4><span style="font-size:x-small;"><span style="font-family:times new roman,times;"><span style="font-size:small;"><span style="font-family:arial,helvetica,sans-serif;"><span style="font-size:small;">Ala5 </sp